E
Eva Szomolanyi-Tsuda
Researcher at University of Massachusetts Medical School
Publications - 39
Citations - 4049
Eva Szomolanyi-Tsuda is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: T cell & Virus. The author has an hindex of 21, co-authored 38 publications receiving 3811 citations. Previous affiliations of Eva Szomolanyi-Tsuda include University of Massachusetts Amherst.
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Journal ArticleDOI
Plasma cell differentiation requires the transcription factor XBP-1
Andreas M. Reimold,Neal N. Iwakoshi,John P. Manis,Prashanth Vallabhajosyula,Eva Szomolanyi-Tsuda,Ellen M. Gravallese,Daniel S. Friend,Michael J. Grusby,Frederick W. Alt,Laurie H. Glimcher +9 more
TL;DR: XBP-1 transcripts were rapidly upregulated in vitro by stimuli that induce plasma-cell differentiation, and were found at high levels in plasma cells from rheumatoid synovium, and when introduced into B-lineage cells, XBP- 1 initiated plasma- cell differentiation.
Journal ArticleDOI
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Vijay A. K. Rathinam,Zhaozhao Jiang,Stephen N. Waggoner,Shrutie Sharma,Leah E. Cole,Lisa Waggoner,Sivapriya Kailasan Vanaja,Brian G. Monks,Sandhya Ganesan,Eicke Latz,Veit Hornung,Stefanie N. Vogel,Eva Szomolanyi-Tsuda,Katherine A. Fitzgerald +13 more
TL;DR: A central role is identified in regulating caspase-1-dependent maturation of IL-1β and IL-18, as well as pyroptosis, in response to synthetic double-stranded DNA, demonstrating the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity.
Journal ArticleDOI
Immunological memory to viral infections.
TL;DR: How T and B cell memory is generated in response to virus infections and how these cells respond when the host is infected again by similar or different viruses are described.
Journal ArticleDOI
The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes
Kishore R. Alugupalli,Rachel M. Gerstein,Jianzhu Chen,Eva Szomolanyi-Tsuda,Robert T. Woodland,John M. Leong +5 more
TL;DR: The model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis is supported, as the efficient resolution of the episodes of moderate level bacteremia by splenectomized mice suggested that MZ B cells do not play the primary role in clearance of this bacterium.
Book ChapterDOI
Control of Infections by NK Cells
TL;DR: The natural immune system consists of preexisting or rapidly inducible effector components as a first line of defense against pathogens to which the host has not previously been exposed.