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Evguenia Bekman
Researcher at Instituto de Medicina Molecular
Publications - 31
Citations - 1445
Evguenia Bekman is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 12, co-authored 30 publications receiving 1264 citations. Previous affiliations of Evguenia Bekman include Instituto Gulbenkian de Ciência & University of Lisbon.
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Journal ArticleDOI
Dosage-sensitive requirement for mouse Dll4 in artery development
Antonio Duarte,Masanori Hirashima,Rui Benedito,Alexandre Trindade,Patrícia Diniz,Evguenia Bekman,Luís Costa,Domingos Henrique,Janet Rossant +8 more
TL;DR: It is shown that the Dll4 ligand alone is required in a dosage-sensitive manner for normal arterial patterning in development, which implicates Dll 4 as the specific mammalian endothelial ligand for autocrine endothelial Notch signaling, and suggests that Dll3 may be a suitable target for intervention in arterial angiogenesis.
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Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo.
Elsa Abranches,Margarida Martins da Silva,Laurent Pradier,Herbert Schulz,Oliver Hummel,Domingos Henrique,Evguenia Bekman +6 more
TL;DR: This work confirms and extends the cellular and molecular parallels between monolayer ES cell neural differentiation and embryonic neural development, revealing in addition novel aspects of the genetic network underlying the multistep process that leads from uncommitted cells to differentiated neurons.
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Expansion of mouse embryonic stem cells on microcarriers
TL;DR: Cytodex‐3, a microporous microcarrier made up of a dextran matrix with a collagen layer at the surface, was tested for its ability to support the expansion of the mouse S25 ES cell line in spinner flasks and favored the preservation of the S25 cells pluripotent state.
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Generation and Characterization of a Novel Mouse Embryonic Stem Cell Line with a Dynamic Reporter of Nanog Expression
TL;DR: A novel reporter ES cell line with a novel Nanog reporter (Nd, from Nanog dynamics), containing a BAC transgene where the short-lived fluorescent protein VNP is placed under Nanog regulation, allowing an accurate monitoring of Nanog’s dynamic expression in the pluripotent state.
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Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis.
Adelaide Fernandes,Ana S. Falcão,Ana S. Falcão,Elsa Abranches,Evguenia Bekman,Domingos Henrique,Lorene M. Lanier,Dora Brites +7 more
TL;DR: The results indicate that UCB reduces the viability of proliferating neural precursors, decreases neurogenesis without affecting astrogliogenesis, and increases cellular dysfunction in differentiating cells.