E
Eyk Schellenberger
Researcher at Charité
Publications - 65
Citations - 2833
Eyk Schellenberger is an academic researcher from Charité. The author has contributed to research in topics: Annexin A5 & Iron oxide nanoparticles. The author has an hindex of 24, co-authored 65 publications receiving 2650 citations. Previous affiliations of Eyk Schellenberger include Humboldt University of Berlin & Harvard University.
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Journal ArticleDOI
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V–Cy5.5 conjugate
Vasilis Ntziachristos,Eyk Schellenberger,Jorge Ripoll,Doreen Yessayan,Edward E. Graves,Alexei A. Bogdanov,Lee Josephson,Ralph Weissleder +7 more
TL;DR: It is shown that tumor response to chemotherapy can be accurately resolved by fluorescence molecular tomography (FMT) with a phosphatidylserine-sensing fluorescent probe based on modified annexins, thus confirming tomographic imaging as a preferred tool for quantitative investigations of fluorescent probes in tissues.
Journal ArticleDOI
Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle.
David E. Sosnovik,Eyk Schellenberger,Matthias Nahrendorf,Mikhail S. Novikov,Takashi Matsui,George Dai,Fred Reynolds,Luanda Grazette,Anthony Rosenzweig,Ralph Weissleder,Lee Josephson +10 more
TL;DR: The ability to image cardiomyocyte apoptosis in vivo with high‐resolution MRI with the novel nanoparticle AnxCLIO‐Cy5.5 is demonstrated to facilitate the development of novel cardioprotective therapies.
Journal Article
Near-Infrared Fluorescent Imaging of Tumor Apoptosis
TL;DR: It is demonstrated that active Cy-annexin can be used as a NIRF probe to image apoptosis from outside an intact living animal and may provide nonradioactive method of measuring the antiproliferative effects of cancer chemotherapeutic regimens.
Journal ArticleDOI
Magneto/optical annexin V, a multimodal protein.
TL;DR: The synthesis of a magneto/optical form of annexin V is described, achieved by reacting the amino-CLIO nanoparticle with Cy5.5 and SPDP, to produce a fluorescent, sulfhydryl reactive nanoparticle that preserved the protein's ability to bind apoptotic Jurkat T cells.
Journal ArticleDOI
Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI.
Eyk Schellenberger,Alexei A. Bogdanov,Dagmar Högemann,Jonathan F. Tait,Ralph Weissleder,Lee Josephson +5 more
TL;DR: Conjugation of annexin V to CLIO affords a strategy for the development of a MRI imaging probe for detecting apoptosis and allowed the identification of cell suspensions containing apoptotic cells by MRI even at very low concentrations of magnetic substrate.