Ezra Vadai

TL;DR: The finding that senescent cells can be eliminated pharmacologically paves the way to new strategies for the treatment of age-related pathologies.

TL;DR: Lung carcinoma clones, characterized by their highly aggressive metastatic behaviour and originating from two independent murine lung tumours, did not express DAP kinase, in contrast to their low-metastatic counterparts, and it is proposed that loss of DAP Kinase expression provides a unique mechanism that links suppression of apoptosis to metastasis.

TL;DR: It is shown that perforin deficient mice accumulate more senescent cells and have a shorter lifespan, and that this phenotype can be reversed with administration of a senolytic drug.

TL;DR: Inactivated IL-6 transfectants were effective when used as a cellular vaccine for experimental immunotherapy of metastasis and prevented metastatic growth of parental highly metastatic D122 cells when immunization of mice was begun after establishment of the primary parental tumors.

TL;DR: A new way to precisely quantify and identify senescent cells in tissues on a single‐cell basis is presented, enabling a deeper understanding of the senescent state in vivo and paves the way for screening of senescence cells for identification of newsenescence biomarkers, genes that bypass senescences or senolytic compounds that eliminate senescent Cells.