A medical probe device comprises a catheter having a stylet guide housing with one or more stylet ports in a side wall thereof and a stylet guide for directing a flexible stylet outward through the stylet port and through intervening tissue at a preselected, adjustable angle to a target tissue. The total catheter assembly includes a stylet guide lumen communicating with the stylet port and a stylet positioned in said stylet guide lumen for longitudinal movement from the port through intervening tissue to a target tissue. The stylet can be an electrical conductor enclosed within a non-conductive layer, the electrical conductor being a radiofrequency electrode. Preferably, the non-conductive layer is a sleeve which is axially moveable on the electrical conductor to expose a selected portion of the electrical conductor surface in the target tissue. The stylet can also be a microwave antenna. The stylet can also be a hollow tube for delivering treatment fluid to the target tissue. It can also include a fiber optic cable for laser treatment. The catheter can include one or more inflatable balloons located adjacent to the stylet port for anchoring the catheter or dilation. Ultrasound transponders and temperature sensors can be attached to the probe end and/or stylet. The stylet guide can define a stylet path from an axial orientation in the catheter through a curved portion to a lateral orientation at the stylet port.

Medical probe device and method

A method for carrying out a medical procedure using a 3-D tracking and imaging system (1600). A surgical instrument, such as a catheter, probe, sensor, pacemaker lead, needle, or the like is inserted into a living being, and the position of the surgical instrument is tracked as it moves through a medium in a bodily structure. The location of the surgical instrument relative to its immediate surroundings is displayed to improve a physician's ability to precisely position the surgical instrument. The medical procedures including targeted drug delivery, sewing sutures, removal of an obstruction from the circulatory system, a biopsy, amniocentesis, brain surgery, measurement of cervical dilation, evaluation of knee stability, assessment of myocardial contractibility, eye surgery, prostate surgery, trans-myocardial revascularization (TMR), robotic surgery, and evaluation of RF transmissions.

A method for carrying out a medical procedure using a three-dimensional tracking and imaging system

A multiple antenna ablation apparatus includes an electromagnetic energy source, a trocar including a distal end, and a hollow lumen extending along a longitudinal axis of the trocar, and a multiple antenna ablation device with three or more antennas. The antennas are initially positioned in the trocar lumen as the trocar is introduced through tissue. At a selected tissue site the antennas are deployable from the trocar lumen in a lateral direction relative to the longitudinal axis. Each of the deployed antennas has an electromagnetic energy delivery surface of sufficient size to, (i) create a volumetric ablation between the deployed antennas, and (ii) the volumetric ablation is achieved without impeding out any of the deployed antennas when 5 to 200 watts of electromagnetic energy is delivered from the electromagnetic energy source to the multiple antenna ablation device. At least one cable couples the multiple antenna ablation device to the electromagnetic energy source.

Multiple antenna ablation apparatus and method

A tissue ablation apparatus includes a delivery catheter with distal and proximal ends. A handle is attached to the proximal end of the delivery catheter. At least partially positioned in the delivery catheter is an electrode deployment device. The electrode deployment device includes a plurality of retractable electrodes. Each electrode has a non-deployed state when it is positioned in the delivery catheter. Additionally, each electrode has a distended deployed state when it is advanced out of the delivery catheter distal end. The deployed electrodes define an ablation volume. Each deployed electrode has a first section with a first radius of curvature. The first section is located near the distal end of the delivery catheter. A second section of the deployed electrode extends beyond the first section, and has a second radius of curvature, or a substantially linear geometry.

Multiple electrode ablation apparatus

A method of this invention for treating body tissues containing cancerous cells or non-malignant tumors with RF ablation, alone or in combination with systemic or localized chemotherapy comprising introducing a stylet comprising an electrode surface and a sleeve longitudinally moveable thereon into the vicinity of the body tissues, retracting the sleeve from a portion of the electrode surface, and supplying RF power to the electrode surface sufficient to heat the tissue to a temperature of above about 45° C. for a time to cause reduction of tissue mass in the vicinity of the electrode. The RF power supplied to the electrode surface is sufficient to effect a desiccated fluid diffusion barrier capsule surrounding the body tissue being treated. The stylet can include a hollow tube having fluid distribution ports therein, and the method can include the step of passing fluid through one or more distribution ports into the body tissue being treated. The fluid can be saline or a chemotherapeutic fluid such as liquid or gas containing a cytotoxic agent, for example. The fluid can be administered in a variety of procedures. The fluid can be passed through a distribution port into the body tissue before, during and/or after the RF power is supplied to the electrode surface, for example. Preferably, the fluid is introduced after a barrier capsule has been formed. The devices comprises electrodes havming a hollow core and a closed sharpened distal tip. The electrode has a plurality of fluid distribution ports therein for distribution of fluid treatment agents into the tissue.

Device for treating cancer and non-malignant tumors and methods

An ultrasonic transducer assembly is provided with transducers for both therapeutic and diagnostic ultrasonic radiation. A moveable seal permits adjustment and alignment of the two transducer units in a fluid medium. In addition, there is provided a light beam directed along the axis of the ultrasonic radiation. The transducer assembly is particularly useful for ophthalmic therapy.

Ultrasonic diagnostic and therapeutic transducer assembly and method for using

A system is described for obtaining in real-time cross-sectional and 3-dimensional images of a body under study using ultrasonic energy. A piezoelectric transducer is positioned to emit ultrasonic energy and receive echo pulses. The transducer is electronically swept or physically rotated to produce a series of sectored scan planes which are separated by a known angular distance. The echo pulses are processed to produce an ultrasonic image in pseudo 3-dimensional display. By using data from one scan plane, processed as a B-scan image, cross-sectional data can be obtained. Such is combined in a display with an overlay to visually portray the object and positioning information or comparative data. The system is combined with a computer for data analysis and a therapeutic transducer for treatment.

System of therapeutic ultrasound and real-time ultrasonic scanning

Therapeutic Ultrasound in the Treatment of Glaucoma: I. Experimental Model

A method and an apparatus for applying a therapeutic substance to body tissue are provided in which ultrasonic radiation is used. The method allows the application of medication to be tailored to the needs of an individual patient. In particular, the timing, duration, intensity, and concentration of the application of medication can be adjusted according to individual requirements. Side effects of tissue adjacent to tissue in need o The invention described herein was made in the course of work under a grant from the National Institute of Health.

F.L. Lizzi

Papers

Ultrasonic diagnostic and therapeutic transducer assembly and method for using

System of therapeutic ultrasound and real-time ultrasonic scanning

Therapeutic Ultrasound in the Treatment of Glaucoma: I. Experimental Model

Local application of medication with ultrasound

Treatment of glaucoma with high-intensity focused ultrasound.