The in vivo biliary elimination of the dietary amine tyramine was studied in protein energy-deficient rats. Tyramine was administered intraperitoneally at single doses of 1200 μg/kg body weight to Kwashiorkor Wistar rats following cannulation of the bile duct. Excretory products in 24-h samples of feces and urine from both Kwashiorkor and normal cannulated rats, who were similarly dosed with tyramine, were also examined. The feces and urine samples were subjected to spectrophotometric and paper chromatographic analyses that showed the presence of tyramine, p-hydroxyphenylethanol, p-hydroxyphenylacetic acid, p-hydroxyphenaceturic acid, and N-acetyltyramine. Thin-layer chromatography of the bile from test rats followed by ultraviolet analysis of the chromatogram confirmed the presence of unchanged tyramine and the metabolite p-hydroxyphenylethanol. The results confirm that the bile is an excretory route for the amines and also that nutrition plays an important role in the pharmacological or toxic action of ...

F. O. Uhegbu

Papers

Elimination of tyramine in protein energy-deficient Wistar rats