F. Rossi Fanelli

TL;DR: The definition of cachexia, pre-cachexia and sarc Openia as well as the criteria for the differentiation between cachexia and other conditions associated with sarcopenia, which have been developed in cooperation with the ESPEN SIG on nutrition in geriatrics are reported.

TL;DR: Investigating whether muscle depletion as occurring in an experimental model of cancer cachexia, the rat bearing the Yoshida AH‐130 hepatoma, is associated with modulations of myostatin signalling and whether the cytokine tumour necrosis factor‐α may be relevant in this regard.

TL;DR: The results support the role of parasympathetic activity in influencing BMI through likely modulation of body weight.

TL;DR: It is demonstrated that muscle depletion in this model is indeed associated with increased proteasome- and calpain-dependent proteolysis, as previously suggested by increased mRNA expression of molecules pertaining to both pathways, and anticytokine treatments effectively reduce muscle protein loss by down-regulating the activity of at least two major proteolitic systems.

TL;DR: Both hyperproduction and hypodegradation seem to be responsible for the high insulin levels in patients with chronic liver failure, and a pathogenetic role of hormones involved in the glucose counterregulating system is failed to establish.