Showing papers by "Fabiana Madotto published in 2009"
TL;DR: Subjects with WCHT and MHT are at increased risk of developing SHT, and independent contributors of worsening of hypertension status were not only baseline BP, but also, although to a lesser extent, metabolic variables and age.
Abstract: It is debated whether white-coat (WCHT) and masked hypertension (MHT) are at greater risk of developing a sustained hypertensive state (SHT). In 1412 subjects of the Pressioni Arteriose Monitorate e Loro Associazioni Study, we measured office blood pressure (BP), 24-hour ambulatory BP, and home BP. The condition of WCHT was identified as office BP >140/90 mm Hg and 24-hour BP mean or =125/79 mm Hg, and home BP >or =132/82 mm Hg. SHT was identified when both office and 24-hour BP means or home BP were over threshold values and normotension was under the threshold value. Subjects were reassessed 10 years later to evaluate the BP status of the various conditions defined previously. At the first examination, 758 (54.1%), 225 (16.1%), 124 (8.9%), and 293 (20.9%) subjects were normotensive, WCHT, MHT, and SHT subjects, respectively. At the second examination, 136 normotensives (18.2%), 95 WCHT (42.6%), and 56 MHT (47.1%) subjects became SHT. As compared with normotensives, adjusting for age and sex, the risk of becoming SHT was significantly higher for WCHT and MHT subjects (odds ratio: 2.51 and 1.78, respectively; P<0.0001). Similar results were obtained when the definition of the various conditions was based on home BP. Independent contributors of worsening of hypertension status were not only baseline BP, but also, although to a lesser extent, metabolic variables and age. Subjects with WCHT and MHT are at increased risk of developing SHT. This may contribute to their prognosis that appears to be worse as compared with that of normotensive subjects.
275 citations
TL;DR: Evidence is provided that LVH is an important risk factor even when the contribution of different BPs to risk is fully taken into account, and left ventricular mass index was always an independent predictor of cardiovascular events and death for any cause.
Abstract: ObjectivesPrevious studies have shown that left ventricular hypertrophy (LVH) represents a cardiovascular risk factor independently of clinic blood pressure (BP). The present study was aimed at determining the impact of LVH on the incidence of cardiovascular morbid and fatal events taking into accou
163 citations
TL;DR: White-coat and masked hypertension are associated with a long-term greater progression of blood glucose abnormalities and an increased risk of developing diabetes.
Abstract: ObjectiveA sustained blood pressure elevation is associated with an increased risk of new-onset diabetes mellitus. Whether this is the case also in white-coat and masked hypertension is unknown.MethodsIn 1412 individuals of the Pressioni Arteriose Monitorate E Loro Associazioni study stratified for
109 citations
Journal Article•
2 citations
1 citations
01 Jan 2009
TL;DR: In this article, the Pressioni Arteriose Monitorate e Loro Associazioni Study was used to evaluate the risk of developing asustained hypertensive state (SHT).
Abstract: —It is debated whether white-coat (WCHT) and masked hypertension (MHT) are at greater risk of developing asustained hypertensive state (SHT). In 1412 subjects of the Pressioni Arteriose Monitorate e Loro Associazioni Study,we measured office blood pressure (BP), 24-hour ambulatory BP, and home BP. The condition of WCHT was identifiedas office BP 140/90 mm Hg and 24-hour BP mean 125/79 mm Hg or home BP 132/82 mm Hg. Correspondingvalues for MHT diagnosis were office BP 140/90 mm Hg, 24-hour BP 125/79 mm Hg, and home BP132/82 mm Hg. SHT was identified when both office and 24-hour BP means or home BP were over threshold valuesand normotension was under the threshold value. Subjects were reassessed 10 years later to evaluate the BP status ofthe various conditions defined previously. At the first examination, 758 (54.1%), 225 (16.1%), 124 (8.9%), and 293(20.9%) subjects were normotensive, WCHT, MHT, and SHT subjects, respectively. At the second examination, 136normotensives (18.2%), 95 WCHT (42.6%), and 56 MHT (47.1%) subjects became SHT. As compared withnormotensives, adjusting for age and sex, the risk of becoming SHT was significantly higher for WCHT and MHTsubjects (odds ratio: 2.51 and 1.78, respectively;
TL;DR: Analysis of the Pressioni Arteriose Monitorate e Loro Associazioni Study population expands on the evidence obtained in the Ohasama Study population, finding that white-coat hypertension, as defined by a high office blood pressure and a normal home BP, was associated with a greater risk of developing sustained hypertension.
Abstract: We thank Obara et al1 for their interest in the results of our analysis of the Pressioni Arteriose Monitorate e Loro Associazioni Study population,2 which expands on the evidence obtained in the Ohasama Study population.3 As mentioned by Ugajin et al,3 in the Ohasama population, white-coat hypertension, as defined by a high office blood pressure (BP) and a normal home BP, was associated with a greater risk of developing sustained (ie, office and home) hypertension as compared with true normotension, that is, the condition in …