F
Fabien Guegan
Researcher at Instituto de Medicina Molecular
Publications - 4
Citations - 309
Fabien Guegan is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Trypanosoma brucei & Cellular differentiation. The author has an hindex of 3, co-authored 4 publications receiving 241 citations.
Papers
More filters
Journal ArticleDOI
Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice.
Sandra Trindade,Filipa Rijo-Ferreira,Filipa Rijo-Ferreira,Filipa Rijo-Ferreira,Tânia Carvalho,Daniel Pinto-Neves,Fabien Guegan,Francisco Aresta-Branco,Fabio Bento,Simon A. Young,Andreia Pinto,Jan Van Den Abbeele,Jan Van Den Abbeele,Ruy M. Ribeiro,Ruy M. Ribeiro,Sergio Dias,Terry K. Smith,Luisa M. Figueiredo +17 more
TL;DR: It is discovered that adipose tissue constitutes a third major reservoir for T. brucei during its mammalian life cycle and could potentially explain the weight loss associated with sleeping sickness.
Journal ArticleDOI
Trypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo.
Ana Cristina Ruiz Peña,Mafalda R. Pimentel,Helena Manso,Rita Vaz-Drago,Daniel Pinto-Neves,Francisco Aresta-Branco,Filipa Rijo-Ferreira,Fabien Guegan,Luis Pedro Coelho,Maria Carmo-Fonseca,Nuno L. Barbosa-Morais,Nuno L. Barbosa-Morais,Luisa M. Figueiredo +12 more
TL;DR: Using RNA sequencing, it is shown that H1 depletion changes the expression of a specific cohort of genes in T. brucei, and that parasites depleted of H1 grow almost normally in culture but they have a reduced fitness in mice, suggesting that H 1 is important for host–pathogen interactions.
Posted ContentDOI
A long non-coding RNA controls parasite differentiation in African trypanosomes
Fabien Guegan,Fabio Bento,Fabio Bento,Neves D,Sequeira M,Cedric Notredame,Luisa M. Figueiredo +6 more
TL;DR: It is suggested that grumpy is one of many lncRNAs that modulate parasite-host interactions, and lncRNA roles in cell differentiation are probably commonplace in T. brucei.
Journal ArticleDOI
Parasite Transmission: A two-stage solution
TL;DR: The parasite that causes African sleeping sickness can be transmitted from mammals to tsetse flies in two stages of its lifecycle, rather than one as was previously thought as mentioned in this paper, which is the first stage of its life cycle.