Fabienne Baffert

TL;DR: Treatment with VEGF signaling inhibitors caused robust and early changes in endothelial cells, pericytes, and basement membrane of vessels in spontaneous islet-cell tumors of RIP-Tag2 transgenic mice and in subcutaneously implanted Lewis lung carcinomas.

TL;DR: It is demonstrated that, after inhibition of VEGF signaling, some normal capillaries regress in a systematic sequence of events initiated by a cessation of blood flow and followed by apoptosis of endothelial cells, migration of pericytes away from regressing vessels, and formation of empty basement membrane sleeves that can facilitate capillary regrowth.

TL;DR: The results suggest that Ang-1 reduces leakage from inflamed venules by restricting the number and size of gaps that form at endothelial cell junctions through effects on intracellular signaling, cytoskeleton, and junction-related molecules.

TL;DR: It is found that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow and that sustained overexpression of Tie2 could participate in the maintenance of vascular changes.

TL;DR: Findings indicate that VEGF and Ang1 participate in blood vessel survival and plasticity in adult life.