Amy Haskell

TL;DR: It is concluded that pericytes are present on most tumor vessels but have multiple abnormalities, including altered expression of marker proteins, which raises the possibility of an involvement in sprout growth or retraction in tumors.

TL;DR: Treatment with VEGF signaling inhibitors caused robust and early changes in endothelial cells, pericytes, and basement membrane of vessels in spontaneous islet-cell tumors of RIP-Tag2 transgenic mice and in subcutaneously implanted Lewis lung carcinomas.

TL;DR: Findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature.

TL;DR: The findings indicate that basement membrane covers most tumor vessels but has profound structural abnormalities, consistent with the dynamic nature of endothelial cells and pericytes in tumors.

TL;DR: It is indicated that angiogenic endothelial cells in these models avidly bind and internalize cationic liposomes and liposome-DNA complexes but not other types ofliposomes, which raises the possibility of using cationsome- DNA complexes to target diagnostic or therapeutic agents selectively toAngiogenic blood vessels in tumors and sites of chronic inflammation.