F
Fakhara Ahmed
Researcher at Wayne State University
Publications - 14
Citations - 1223
Fakhara Ahmed is an academic researcher from Wayne State University. The author has contributed to research in topics: Cell growth & Growth inhibition. The author has an hindex of 11, co-authored 14 publications receiving 1151 citations.
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Journal ArticleDOI
Inactivation of Nuclear Factor κB by Soy Isoflavone Genistein Contributes to Increased Apoptosis Induced by Chemotherapeutic Agents in Human Cancer Cells
TL;DR: It is suggested that genistein pretreatment inactivates NF-kappaB and may contribute to increased growth inhibition and apoptosis induced by cisplatin, docetaxel, and doxorubicin in prostate, breast, lung, and pancreatic cancer cells.
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Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells.
Shreelekha Adsule,Vivek Barve,Di Chen,Fakhara Ahmed,Q. Ping Dou,Subhash Padhye,Fazlul H. Sarkar +6 more
TL;DR: It is found that quinoline thiosemicarbazone 2 was the most potent and inhibited proteosome activity in intact human prostate cancer PC-3 and LNCaP cells (IC50 of 4 and 3.2 microM, respectively) compared to clioquinol and pyrrolidine dithiocarbamate.
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Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells.
Vivek Barve,Fakhara Ahmed,Shreelekha Adsule,Sanjeev Banerjee,Sudhir Kulkarni,Prashant Katiyar,Christopher E. Anson,Annie K. Powell,Subhash Padhye,Fazlul H. Sarkar +9 more
TL;DR: In vitro evaluation of copper complexes against hormone-independent and metastatic breast and prostate cancer cells revealed that 7 was the most potent compound which exhibited PKB (Akt protein) inhibitory activities and caused NF-kappaB inactivation in a well-established orthotopic pancreatic tumor model using COLO 357 cells.
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Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells.
Mohammad Bhuiyan,Yiwei Li,Sanjeev Banerjee,Fakhara Ahmed,Zhiwei Wang,Shadan Ali,Fazlul H. Sarkar +6 more
TL;DR: The results suggest that B-DIM-induced cell proliferation inhibition and apoptosis induction are partly mediated through the down-regulation of AR, Akt, and NF-kappaB signaling in hormone-sensitive and hormone-insensitive prostate cancer cells.
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Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells
TL;DR: This article has been retracted at the request of the editor‐in‐Chief and co‐author because of a lack of original research.