F
Fang-Yu Chen
Researcher at National Central University
Publications - 12
Citations - 2187
Fang-Yu Chen is an academic researcher from National Central University. The author has contributed to research in topics: Lipid bilayer & Membrane fluidity. The author has an hindex of 12, co-authored 12 publications receiving 2023 citations. Previous affiliations of Fang-Yu Chen include Rice University.
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The condensing effect of cholesterol in lipid bilayers.
TL;DR: The condensing effect of cholesterol on phospholipid bilayers was systematically investigated for saturated and unsaturated chains, as a function of cholesterol concentration, using X-ray lamellar diffraction to measure the phosphate-to-phosphate distances.
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Molecular mechanism of Peptide-induced pores in membranes.
TL;DR: A physical mechanism by which antimicrobial peptides spontaneously induce stable pores in membranes is suggested, which resembles a phase transition.
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Energetics of pore formation induced by membrane active peptides
TL;DR: This work uses two of the best-studied peptides, alamethicin and melittin, to represent peptides making two types of pores, that is, barrel-stave pores and toroidal pores, and extracts experimental parameters that are useful for further molecular analysis and for molecular dynamic simulation studies.
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Evidence for membrane thinning effect as the mechanism for peptide-induced pore formation.
TL;DR: The full implications of the free energy were tested by including another type of peptide, melittin, that forms toroidal pores, instead of barrel-stave pores as in the case of alamethicin, indicating that the membrane thinning effect is a plausible mechanism for the peptide-induced pore formations.
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Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptides
TL;DR: The mechanism includes a negative feedback that makes peptide-induced pores stable with a well defined size, contrary to the suggestion that peptides disintegrate the membrane in a detergent-like manner.