F
Fangcai Li
Researcher at Zhejiang University
Publications - 26
Citations - 675
Fangcai Li is an academic researcher from Zhejiang University. The author has contributed to research in topics: Mesenchymal stem cell & PLGA. The author has an hindex of 13, co-authored 26 publications receiving 517 citations.
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Journal ArticleDOI
Responses of human adipose-derived mesenchymal stem cells to chemical microenvironment of the intervertebral disc
TL;DR: Findings may promote the translational research of ADMSCs in IVD regeneration for the treatment of low back pain and stop IVD-like high osmolarity and low pH are deleterious factors that affect the survival and biological behaviors of AD MSCs.
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Nucleus pulposus mesenchymal stem cells in acidic conditions mimicking degenerative intervertebral discs give better performance than adipose tissue-derived mesenchymal stem cells.
TL;DR: Compared with ADMSCs, NPMSCs appeared less sensitive to inhibition by acidic pH and might be promising candidates for cell-based IVD regeneration.
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Influence of Hypoxia in the Intervertebral Disc on the Biological Behaviors of Rat Adipose- and Nucleus Pulposus-Derived Mesenchymal Stem Cells
TL;DR: In conclusion, hypoxia in the IVD had a significant impact on the viability, proliferation and chondrocytic differentiation of ADMSCs and NPMSCs, and may represent another candidate for cell-based therapy for IVD regeneration.
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Dual release of dexamethasone and TGF-β3 from polymeric microspheres for stem cell matrix accumulation in a rat disc degeneration model.
Chengzhen Liang,Hao Li,Yiqing Tao,Li-hua Peng,Jian-Qing Gao,Jing-jun Wu,Fangcai Li,Jianming Hua,Qixin Chen +8 more
TL;DR: Data suggest that ADSC-seeded PLGA microspheres could partly regenerate the degenerated disc in vivo after implantation into the rat degenerative intervertebral disc.
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Cervical Total Disc Replacement is Superior to Anterior Cervical Decompression and Fusion: A Meta-Analysis of Prospective Randomized Controlled Trials
TL;DR: The efficacy and safety of cervical total disc replacement are superior to those of fusion, and longer-term, multicenter studies are required for a better evaluation of the long-term efficacy andsafety of the two procedures.