Journal ArticleDOI
Dual release of dexamethasone and TGF-β3 from polymeric microspheres for stem cell matrix accumulation in a rat disc degeneration model.
Chengzhen Liang,Hao Li,Yiqing Tao,Li-hua Peng,Jian-Qing Gao,Jing-jun Wu,Fangcai Li,Jianming Hua,Qixin Chen +8 more
TLDR
Data suggest that ADSC-seeded PLGA microspheres could partly regenerate the degenerated disc in vivo after implantation into the rat degenerative intervertebral disc.About:
This article is published in Acta Biomaterialia.The article was published on 2013-12-01. It has received 65 citations till now. The article focuses on the topics: PLGA & Intervertebral disc.read more
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Journal ArticleDOI
Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies.
TL;DR: With advanced study of tissue engineering protocols based on cell therapy, combined use of seeding cells, bio‐active substances and bio‐compatible materials, are promising for IDD regeneration.
Journal ArticleDOI
Engineering Stem and Stromal Cell Therapies for Musculoskeletal Tissue Repair
Claudia Loebel,Jason A. Burdick +1 more
TL;DR: Recent clinical advances where stem cells and stromal cells have been used to stimulate musculoskeletal tissue repair, including delivery strategies to improve cell viability and retention are presented.
Journal ArticleDOI
Innovative strategies for intervertebral disc regenerative medicine: From cell therapies to multiscale delivery systems.
TL;DR: This review highlights the IVD-relevant polymers as well as their design as macro-, micro-, and nano-sized particles to promote endogenous repair and illustrates how multiscale systems, combining in situ-forming hydrogels with ready-to-use particles, might drive IVD regenerative medicine strategies toward innovation.
Journal ArticleDOI
Delivery systems for the treatment of degenerated intervertebral discs.
TL;DR: Alternative strategies to increase and prolong the effects of bioactive agents and to reverse the process of IVD degeneration include the use of delivery systems for drugs, proteins, cells and genes which are reviewed in this article.
Journal ArticleDOI
Genipin cross-linked type II collagen/chondroitin sulfate composite hydrogel-like cell delivery system induces differentiation of adipose-derived stem cells and regenerates degenerated nucleus pulposus.
Xiaopeng Zhou,Jingkai Wang,Weijing Fang,Yiqing Tao,Tengfei Zhao,Kaishun Xia,Chengzhen Liang,Jianming Hua,Fangcai Li,Qixin Chen +9 more
TL;DR: The results showed that the CCSA delivery system cross-linked with 0.02% genipin was biocompatible and promoted the expressions of NP-specific genes and provided an exciting new avenue for the treatment of degenerative disc disease.
References
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Journal ArticleDOI
Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue.
TL;DR: Both UCB and AT are attractive alternatives to BM in isolating MSC: AT as it contains MSCs at the highest frequency and UCB as it seems to be expandable to higher numbers.
Journal ArticleDOI
Cell replacement therapies for central nervous system disorders.
Anders Björklund,Olle Lindvall +1 more
TL;DR: In animal models, immature neural precursors can replace lost neurons, restore function and promote brain self-repair and clinical trials in Parkinson's disease suggest that similar approaches may also work in the diseased human brain.
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Human marrow stromal cell therapy for stroke in rat Neurotrophins and functional recovery
Yi Li,Jieli Chen,X. G. Chen,L. Wang,Subhash C. Gautam,Y.X. Xu,Mark Katakowski,Lijie Zhang,Mei Lu,N. Janakiraman,Michael Chopp +10 more
TL;DR: Neurologic benefit resulting from hMSC treatment of stroke in rats may derive from the increase of growth factors in the ischemic tissue, the reduction of apoptosis in the penumbral zone of the lesion, and the proliferation of endogenous cells in the subventricular zone.
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Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue
Reza Izadpanah,Cynthia B. Trygg,Bindiya Patel,Christopher Kriedt,Jason Dufour,Jeffery M. Gimble,Bruce A. Bunnell +6 more
TL;DR: Overall in vitro characterization of MSCs from these two species and tissue sources revealed a high level of common biologic properties, however, the results demonstrate clear biologic distinctions, as well.
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Treatment of neural injury with marrow stromal cells
Michael Chopp,Yi Li +1 more
TL;DR: There is justification for further preclinical studies leading to clinical trials for the treatment of neural injury such as stroke due to the robust therapeutic benefit of bone-marrow stromal cells.