F
Fangnian Wang
Researcher at Boston University
Publications - 2
Citations - 242
Fangnian Wang is an academic researcher from Boston University. The author has contributed to research in topics: Insulin resistance & Adipogenesis. The author has an hindex of 2, co-authored 2 publications receiving 221 citations.
Papers
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Journal ArticleDOI
Brd2 disruption in mice causes severe obesity without Type 2 diabetes.
Fangnian Wang,Hongsheng Liu,Wanda P. Blanton,Anna C. Belkina,Nathan K. LeBrasseur,Gerald V. Denis +5 more
TL;DR: Hypomorphic Brd2 shifts energy balance toward storage without causing glucose intolerance and may provide a novel model for obese metabolically healthy humans.
Book ChapterDOI
Brd2 gene disruption causes "metabolically healthy" obesity: epigenetic and chromatin-based mechanisms that uncouple obesity from type 2 diabetes.
TL;DR: In the severely obese state, Brd2 knockdown in mice prevented obesity-induced inflammatory responses, protected animals from insulin resistance, glucose intolerance and pancreatic beta cell dysfunction, and thus uncoupled obesity from diabetes.