F
Farina Bendt
Researcher at Leibniz Association
Publications - 18
Citations - 386
Farina Bendt is an academic researcher from Leibniz Association. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 12 publications receiving 214 citations.
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Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events.
Jenny Baumann,Kathrin Gassmann,Stefan Masjosthusmann,Denise DeBoer,Farina Bendt,Susanne Giersiefer,Ellen Fritsche +6 more
TL;DR: An in vitro model for DNT key event screening is developed based on primary human and rat neural progenitor cells grown as neurospheres, which is able to mimic basic processes of early fetal brain development and enable an investigation of species differences between humans and rodents in corresponding cellular models.
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Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro
Martin Schmuck,Thomas Temme,Katharina Dach,Denise de Boer,Marta Barenys,Farina Bendt,Axel Mosig,Ellen Fritsche +7 more
TL;DR: Omnisphero software, which assesses multiple endpoints of the ‘Neurosphere Assay’ and includes novel algorithms to assess ‘neurospheres-specific’ endpoints like radial migration and neuronal density distribution within the migration area, makes Omnisphero accessible to non-expert end users.
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BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action.
Katharina Dach,Farina Bendt,Ulrike Huebenthal,Susanne Giersiefer,Pamela J. Lein,Heike Heuer,Ellen Fritsche +6 more
TL;DR: Data point to species-specific modes of action of BDE-99 on h/mNPC development into the oligodendrocyte lineage as well as ascorbic acid antagonized only the Bde-99-dependent loss of human, not mouse, O4+ cells by a mechanism probably independent of reactive oxygen species.
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Establishment of an a priori protocol for the implementation and interpretation of an in-vitro testing battery for the assessment of developmental neurotoxicity
Stefan Masjosthusmann,Jonathan Blum,Kristina Bartmann,Xenia Dolde,Anna-Katharina Holzer,Lynn-Christin Stürzl,Eike Hagen Keßel,Nils Förster,Arif Dönmez,Jördis Klose,Melanie Pahl,Tanja Waldmann,Farina Bendt,Jaffar Kisitu,Ilinca Suciu,Ulrike Hübenthal,Axel Mosig,Marcel Leist,Ellen Fritsche +18 more
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Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro.
Marta Barenys,Kathrin Gassmann,Christine Baksmeier,Sabrina Heinz,Ingrid Reverte,Martin Schmuck,Thomas Temme,Farina Bendt,Tim-Christian Zschauer,Thomas Dino Rockel,Klaus Unfried,Wim Wätjen,Sivaraj Mohana Sundaram,Heike Heuer,Maria Teresa Colomina,Ellen Fritsche +15 more
TL;DR: This work aimed to characterize the neurodevelopmental effects of the green tea catechin epigallocatechin gallate (EGCG), which is now commercialized as high-dose food supplement, and used the “Neurosphere Assay” to study the effects and unravel underlying molecular mechanisms of EGCG treatment on human and rat neural progenitor cells (NPCs) development in vitro.