F
Fatima Bosch
Researcher at Autonomous University of Barcelona
Publications - 186
Citations - 8923
Fatima Bosch is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Insulin & Adipose tissue. The author has an hindex of 50, co-authored 175 publications receiving 7920 citations. Previous affiliations of Fatima Bosch include University of Barcelona & Carlos III Health Institute.
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Journal ArticleDOI
Telomerase Gene Therapy in Adult and Old Mice Delays Aging and Increases Longevity Without Increasing Cancer
Bruno Bernardes de Jesus,Elsa Vera,Kerstin Schneeberger,Agueda M. Tejera,Eduard Ayuso,Fatima Bosch,Maria A. Blasco +6 more
TL;DR: A proof‐of‐principle of a role of TERT in delaying physiological aging and extending longevity in normal mice through a telomerase‐based treatment is formed, and the feasibility of anti‐aging gene therapy is demonstrated.
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Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus
TL;DR: This animal model shows that primary alterations in the rate of liver glucose production may induce insulin resistance and NIDDM.
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Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance
Ivet Elias,Sylvie Franckhauser,Tura Ferre,Laia Vilà,Sabrina Tafuro,Sergio Muñoz,Carles Roca,David Ramos,Anna Pujol,Efren Riu,Jesús Ruberte,Fatima Bosch +11 more
TL;DR: It is suggested that overexpression of VEGF in adipose tissue is a potential therapeutic strategy for the prevention of obesity and insulin resistance.
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High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency
Eduard Ayuso,F Mingozzi,Joel Montane,Xavier León,Xavier M. Anguela,Virginia Haurigot,Virginia Haurigot,Shyrie Edmonson,Shyrie Edmonson,L Africa,Shangzhen Zhou,Katherine A. High,Katherine A. High,Fatima Bosch,J F Wright,J F Wright +15 more
TL;DR: Vectors purified by the optimized CsCl protocol were found to be comparable in purity and functional activity to those prepared by more scalable, but less flexible serotype-specific purification processes developed for manufacture of clinical vectors, and are ideally suited for pre-clinical studies supporting translational research.
Journal ArticleDOI
Increased Fatty Acid Re-esterification by PEPCK Overexpression in Adipose Tissue Leads to Obesity Without Insulin Resistance
Sylvie Franckhauser,Sergio Muñoz,Anna Pujol,Alba Casellas,Efren Riu,Pedro J. Otaegui,Benli Su,Fatima Bosch +7 more
TL;DR: The results suggest that higher fat mass without increased circulating FFAs does not lead to insulin resistance or type 2 diabetes in these mice, and the key role of PEPCK in the control of FFA re-esterification in adipose tissue is indicated.