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Xavier León
Researcher at Autonomous University of Barcelona
Publications - 229
Citations - 5776
Xavier León is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Medicine. The author has an hindex of 36, co-authored 201 publications receiving 4802 citations. Previous affiliations of Xavier León include Complutense University of Madrid & Carlos III Health Institute.
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Journal ArticleDOI
HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients
Xavier Castellsagué,Laia Alemany,Miquel Quer,Gordana Halec,Beatriz Quirós,Sara Tous,Omar Clavero,Llucia Alos,Thorsten Biegner,Tomasz Szafarowski,Maria Alejo,Dana Holzinger,Enrique Cadena,Edith Claros,Gillian Hall,Jan Laco,Mario Poljak,Maria Benevolo,Elena Kasamatsu,Hisham Mehanna,Cathy Ndiaye,Núria Guimerà,Belen Lloveras,Xavier León,Juan C. Ruiz-Cabezas,Isabel Alvarado-Cabrero,Chang Suk Kang,Jin-Kyoung Oh,Marcial Garcia-Rojo,Ermina Iljazovic,Oluseyi F. Ajayi,Flora Duarte,Ashrafun Nessa,Leopoldo Tinoco,Marco A. Duran-Padilla,Edyta C. Pirog,Halina Viarheichyk,Hesler Morales,Valérie Costes,Ana Félix,Maria Julieta V Germar,Marisa Mena,Arzu Ruacan,Asha Jain,Ravi Mehrotra,Marc T. Goodman,Luis Estuardo Lombardi,Annabelle Ferrera,Sani Malami,Estela I. Albanesi,Pablo Dabed,Carla Molina,Rubén López-Revilla,Václav Mandys,Manuel E. González,Julio Velasco,Ignacio G. Bravo,Wim Quint,Michael Pawlita,Nubia Muñoz,Silvia de Sanjosé,F. Xavier Bosch +61 more
TL;DR: This large international study to estimate fractions of head and neck cancers attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation confirms the important role ofHPVs in oropharyngeal cancer and drastically downplays the previously reported involvement of HPVs in the other HNCs.
Journal ArticleDOI
Second neoplasm in patients with head and neck cancer.
TL;DR: The improvement in locoregional control of head and neck carcinomas over the last decades does not appear to modify the final survival of these patients, mainly due to the appearance of distant metastases and second neoplasms.
Journal ArticleDOI
High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency
Eduard Ayuso,F Mingozzi,Joel Montane,Xavier León,Xavier M. Anguela,Virginia Haurigot,Virginia Haurigot,Shyrie Edmonson,Shyrie Edmonson,L Africa,Shangzhen Zhou,Katherine A. High,Katherine A. High,Fatima Bosch,J F Wright,J F Wright +15 more
TL;DR: Vectors purified by the optimized CsCl protocol were found to be comparable in purity and functional activity to those prepared by more scalable, but less flexible serotype-specific purification processes developed for manufacture of clinical vectors, and are ideally suited for pre-clinical studies supporting translational research.
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Distant metastases in head and neck cancer patients who achieved loco-regional control
TL;DR: The objective of this study was to evaluate the frequency of distant metastases in patients with head and neck carcinoma and to determine the relative role of several prognostic factors in the subsequent development of distant cancer metastases.
Journal ArticleDOI
FGF21 gene therapy as treatment for obesity and insulin resistance
Veronica Jimenez,Claudia Jambrina,Estefania Casana,Victor Sacristan,Sergio Muñoz,Sara Darriba,Jordi Rodó,Cristina Mallol,Miquel Garcia,Xavier León,Sara Marcó,Albert Ribera,Ivet Elias,Alba Casellas,Ignasi Grass,Gemma Elias,Tura Ferre,Sandra Motas,Sylvie Franckhauser,Francisca Mulero,Marc Navarro,Virginia Haurigot,Jesús Ruberte,Fatima Bosch +23 more
TL;DR: FGF21 overproduction in healthy animals fed a standard diet prevented the increase in weight and insulin resistance associated with aging and underscores the potential of FGF21 gene therapy to treat obesity, insulin resistance, and T2D.