F
Federica Barutta
Researcher at University of Turin
Publications - 60
Citations - 2226
Federica Barutta is an academic researcher from University of Turin. The author has contributed to research in topics: Diabetes mellitus & Diabetic nephropathy. The author has an hindex of 23, co-authored 54 publications receiving 1679 citations.
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Journal ArticleDOI
Urinary exosomal microRNAs in incipient diabetic nephropathy.
Federica Barutta,Marinella Tricarico,Alessandro Corbelli,Laura Annaratone,Silvia Pinach,Serena Grimaldi,Graziella Bruno,Daniela Cimino,Daniela Taverna,Maria Chiara Deregibus,Maria Pia Rastaldi,Paolo Cavallo Perin,Gabriella Gruden +12 more
TL;DR: In this article, the miRNA expression in urinary exosomes from type 1 diabetic patients with and without incipient diabetic nephropathy was assessed and miR-145 levels were increased and this was paralleled by miR145 overexpression within the glomeruli.
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Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy.
Federica Barutta,Alessandro Corbelli,Raffaella Mastrocola,Roberto Gambino,Vincenzo Di Marzo,Silvia Pinach,Maria Pia Rastaldi,Paolo Cavallo Perin,Gabriella Gruden +8 more
TL;DR: In experimental type 1 diabetes, theCB1 receptor is overexpressed by glomerular podocytes, and blockade of the CB1 receptor ameliorates albuminuria possibly via prevention of nephrin, podocin, and ZO-1 loss.
Journal ArticleDOI
Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy
Federica Barutta,Fabiana Piscitelli,Silvia Pinach,Graziella Bruno,Roberto Gambino,Maria Pia Rastaldi,Gennaro Salvidio,Vincenzo Di Marzo,Paolo Cavallo Perin,Gabriella Gruden +9 more
TL;DR: The CB2 receptor is expressed by podocytes, and in experimental diabetes, CB2 activation ameliorates both albuminuria and podocyte protein loss, suggesting a protective effect of signaling through CB2 in DN.
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Effect of the Monocyte Chemoattractant Protein-1/CC Chemokine Receptor 2 System on Nephrin Expression in Streptozotocin-Treated Mice and Human Cultured Podocytes
Elena Tarabra,Sara Giunti,Federica Barutta,Gennaro Salvidio,Davina Judith Burt,Giacomo Deferrari,Roberto Gambino,Daniela Vergola,Silvia Pinach,Paolo Cavallo Perin,Giovanni Camussi,Gabriella Gruden +11 more
TL;DR: In human podocytes, MCP-1 binding to the CCR2 receptor induced a significant reduction in nephrin both mRNA and protein expression via a Rho-dependent mechanism, suggesting that the MCP/CCR2 system may be relevant in the pathogenesis of proteinuria in diabetes.
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Role of the endocannabinoid system in diabetes and diabetic complications.
TL;DR: An update on the contribution of the ECS to the pathogenesis of diabetes and diabetic microvascular (retinopathy, nephropathy and neuropathy) and cardiovascular complications is provided and the therapeutic potential of targeting the E CS is discussed.