Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

Machine learning

Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Communications of the ACM (CACM for short, not the best sounding acronym around) is the ACM’s flagship magazine. Started in 1957, CACM is handy for keeping up to date on current research being carried out across all topics of computer science and realworld applications. CACM has had an illustrious past with many influential pieces of work and debates started within its pages. These include Hoare’s presentation of the Quicksort algorithm; Rivest, Shamir and Adleman’s description of the first publickey cryptosystem RSA; and Dijkstra’s famous letter against the use of GOTO. In addition to the print edition, which is released monthly, there is a fantastic website (http://cacm.acm. org/) that showcases not only the most recent edition but all previous CACM articles as well, readable online as well as downloadable as a PDF. In addition, the website lets you browse for articles by subject, a handy feature if you want to focus on a particular topic. CACM is really essential reading. Pretty much guaranteed to contain content that is interesting to anyone, it keeps tabs on the latest in computer science. It is a valuable asset for us students, who tend to delve deep into a particular area of CS and forget everything that is happening around us. — Daniel Gooch U ndergraduate research is like a box of chocolates: You never know what kind of project you will get. That being said, there are still a few things you should know to get the most out of the experience.

Communications of the ACM

This book primarily discusses issues related to the mining aspects of data streams and it is unique in its primary focus on the subject This volume covers mining aspects of data streams comprehensively: each contributed chapter contains a survey on the topic, the key ideas in the field for that particular topic, and future research directions The book is intended for a professional audience composed of researchers and practitioners in industry This book is also appropriate for advanced-level students in computer science

Data Streams: Models and Algorithms

With rising importance of knowledge interchange, many industrial and academic applications have adopted ontologies as their conceptual backbone. However, industrial and academic environments are very dynamic, thus inducing changes to application requirements. To fulfill these changes, often the underlying ontology must be evolved as well. As ontologies grow in size, the complexity of change management increases, thus requiring a well-structured ontology evolution process. In this paper we identify a possible six-phase evolution process and focus on providing the user with capabilities to control and customize it. We introduce the concept of an evolution strategy encapsulating policy for evolution with respect to user?s requirements.

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User-Driven Ontology Evolution Management

Clinical practice is evolving rapidly, away from the traditional but inefficient detect-and-cure approach, and towards a Preventive, Predictive, Personalised and Participative (P4) vision that focuses on extending people’s wellness state. This vision is increasingly data–driven, AI–based, and is underpinned by many forms of “Big Health Data” including periodic clinical assessments and electronic health records, but also using new forms of self–assessment, such as mobile–based questionnaires and personal wearable devices. Over the last few years, we have been conducting a fruitful research collaboration with the Infectious Disease Clinic of the University Hospital of Modena having the main aim of exploring specific opportunities offered by data–driven AI–based approaches to support diagnosis, hospital organization and clinical research. Drawing from this experience, in this paper we provide an overview of the main research challenges that need to be addressed to design and implement data–driven healthcare applications. We present concrete instantiations of these challenges in three real–world use cases and summarise the specific solutions we devised to address them and, finally, we propose a research agenda that outlines the future of research in this field.

Data-Driven, AI-Based Clinical Practice: Experiences, Challenges, and Research Directions

We present the current version of STRIDER, a versatile system for the disambiguation of structure-based information like XML schemas, structures of XML documents and web directories. It can be of support to the semantic-awareness of a wide range of applications, thanks to its novel and fully-automated disambiguation algorithms.

Disambiguation of Structure-Based Information in the STRIDER System

Semantic Web service discovery and composition frameworks proposed so far assume for the most part a centralized registry that holds information of all the Web services available at any given time. This solution does not well cope with the scalability and flexibility requirements of dynamic, fast changing contexts. As part of the NeP4B project, in this paper we propose an alternative peer to peer architecture based on the

Semantic Web Service Composition in the NeP4B Project: Challenges and Architectural Issues

In this paper, we present the preliminary results of the ongoing research activity we are carrying out in the context of approximate XML query answering when the schemas of the XML documents are available. The method we propose involves a preliminary schema matching process, which automatically identifies the semantic and structural similarities between the schema elements to be used in the subsequent operation of query rewriting, in which a query written on a source schema is automatically rewritten in order to be compatible with the other useful XML documents. The proposed approach has been implemented in a web service, named XML SMART, which is part of the open architecture proposed in the ongoing Italian CNR co-funded ECD Project.

Exploiting related digital library corpora with query rewriting.

The Covid-19 crisis caught health care services around the world by surprise, putting unprecedented pressure on Intensive Care Units (ICU) To help clinical staff to manage the limited ICU capacity, we have developed a Machine Learning model to estimate the probability that a patient admitted to hospital with COVID-19 symptoms would develop severe respiratory failure and require Intensive Care within 48 hours of admission The model was trained on an initial cohort of 198 patients admitted to the Infectious Disease ward of Modena University Hospital, in Italy, at the peak of the epidemic, and subsequently refined as more patients were admitted Using the Light- GBM Decision Tree ensemble approach, we were able to achieve good accuracy (AUC = 0 84) despite a high rate of missing values Furthermore, we have been able to provide clinicians with explanations in the form of personalised ranked lists of features for each prediction, using only 20 out of more than 90 variables, using Shapley values to describe the importance of each feature Copyright © 2020 for this paper by its authors

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Federica Mandreoli

Papers

Data-Driven, AI-Based Clinical Practice: Experiences, Challenges, and Research Directions

Disambiguation of Structure-Based Information in the STRIDER System

Semantic Web Service Composition in the NeP4B Project: Challenges and Architectural Issues

Exploiting related digital library corpora with query rewriting.

Predicting respiratory failure in patients with COVID-19 pneumonia: A case study from Northern Italy