F
Federica Raguseo
Researcher at Imperial College London
Publications - 10
Citations - 172
Federica Raguseo is an academic researcher from Imperial College London. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 3 publications receiving 52 citations.
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Journal ArticleDOI
DNA G-quadruplex structures: more than simple roadblocks to transcription?
Jenna Robinson,Federica Raguseo,Sabrina Pia Nuccio,Denise Liano,Marco Di Antonio,Marco Di Antonio +5 more
TL;DR: In this article, the formation of G-quadruplex (G4) secondary structures in gene promoters was first linked to the regulation of gene expression, and a model that placed these non-canonical DNA structures as repressors of transcription by preventing polymerase processivity was proposed.
Journal ArticleDOI
Chemical-biology approaches to probe DNA and RNA G-quadruplex structures in the genome.
TL;DR: This review critically presents the most relevant methods developed to investigate G- quadruplex prevalence in human cells and to study their biological functions, presenting the next key chemical-biology challenges that need to be addressed to fully unravel G-quadruplex mediated biology and their therapeutic potential.
Journal ArticleDOI
A short peptide that preferentially binds c-MYC G-quadruplex DNA
Aisling Minard,Danielle C. Morgan,Federica Raguseo,Anna Di Porzio,Anna Di Porzio,Denise Liano,Andrew G. Jamieson,Marco Di Antonio +7 more
TL;DR: This work took inspiration from a crystal structure of the bovine DHX36 helicase bound to the G4 formed in the promoter region of the oncogene c-MYC to identify a short peptide that preferentially binds MYC G4 with nM affinity over a small panel of parallel and non-parallel G4s tested.
Journal ArticleDOI
Long-range DNA interactions: inter-molecular G-quadruplexes and their potential biological relevance
TL;DR: How the potential for formation of iG4s in neuronal cells, triggered by repeat expansions in the C9orf72 gene, can lead to the formation of nucleic-acids based pathological aggregates in neurodegenerative diseases like ALS and FTD is discussed.
Posted ContentDOI
A synthetic signalling network imitating the action of immune cells in response to bacterial metabolism
Michael E Walczak,Leonardo Mancini,Jiayi Xu,Federica Raguseo,Jurij Kotar,Pietro Cicuta,Lorenzo Di Michele +6 more
TL;DR: In this paper , a consortium consisting of two synthetic agents, responsive DNA-based particles and antibiotic-loaded lipid vesicles, whose coordinated action mimics the sought immune-like response when triggered by bacterial metabolism was proposed.