Showing papers by "Felix T. Wieland published in 2020"

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Journal Article•DOI•

Structural characterization of an Arf dimer interface: molecular mechanism of Arf-dependent membrane scission

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Petra Diestelkoetter‐Bachert¹, Rainer D. Beck¹, Inge Reckmann¹, Andrea Hellwig¹, Ana J. García-Sáez², Monika Zelman‐Hopf, Anton Hanke³, Ariane Nunes Alves³, Rebecca C. Wade⁴, Rebecca C. Wade³, Matthias P. Mayer, Felix T. Wieland¹ - Show less +8 more•Institutions (4)

Heidelberg University¹, University of Cologne², Heidelberg Institute for Theoretical Studies³, Interdisciplinary Center for Scientific Computing⁴

01 Jul 2020-FEBS Letters

TL;DR: The monomer/dimer equilibrium of Arf within the membrane is quantified and it is shown that after membrane scission, Arf dimers are restricted to donor membranes.

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11 citations

Journal Article•DOI•

Epsin but not AP-2 supports reconstitution of endocytic clathrin-coated vesicles.

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Jan Brod¹, Andrea Hellwig¹, Felix T. Wieland¹•Institutions (1)

Heidelberg University¹

01 Jul 2020-FEBS Letters

TL;DR: Epsin‐1 is an important factor for the maturation of clathrin coated buds, a prerequisite for vesicle generation, and the results support the predominant model in which hydrolysis of GTP by dynamin is a prerequisite to generate CCVs.

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7 citations