Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases.

Novel quinoline incorporating 1,2,4-triazole/oxime hybrids: Synthesis, molecular docking, anti-inflammatory, COX inhibition, ulceroginicity and histopathological investigations.

New quinoline/chalcone hybrids as anti-cancer agents: Design, synthesis, and evaluations of cytotoxicity and PI3K inhibitory activity.

Synthesis, characterization, DNA interaction and antibacterial activities of two tetranuclear cobalt(II) and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone

NO-releasing STAT3 inhibitors suppress BRAF-mutant melanoma growth

2-Hydroxybenzylidene-2-phenylquinoline-4-carbonylhydrazone (H2L) and five Ln(III) complexes, [Ln(H2L)(NO3)2]NO3 [Ln = La (1), Pr (2), Sm (3), Eu (4), and Tb (5)], have been synthesized and characterized by 1H NMR, elemental analysis, conductivity measurements, mass spectra, IR spectra, and UV spectra. The interaction of these complexes with calf thymus DNA was investigated by UV absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy and viscosity measurements. Results suggest that these complexes bind to DNA via groove binding.

Feng Juan Chen

Papers

Synthesis, characterization, and DNA-binding of Ln(III) complexes with 2-hydroxybenzylidene-2-phenylquinoline-4-carbonylhydrazone