F
Fengming Chu
Researcher at Peking Union Medical College
Publications - 15
Citations - 386
Fengming Chu is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Agonist & PPAR agonist. The author has an hindex of 10, co-authored 14 publications receiving 339 citations.
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Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: a new series of selective COX-2 inhibitors.
TL;DR: 2-aminosulfonylphenyl-3- phenyl-indole 5a is the discovery which possesses higher activity and selectivity for COX-2 than Celecoxib both in vitro and in vivo.
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Exploration of a binding mode of indole amide analogues as potent histone deacetylase inhibitors and 3D-QSAR analyses
TL;DR: Docking simulations and three-dimensional quantitative structure-activity relationship analyses were conducted on a series of indole amide analogues as potent histone deacetylase inhibitors to provide insight into inhibitor-HDAC interactions at the molecular level.
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Discovery of 2-phenyl-3-sulfonylphenyl-indole derivatives as a new class of selective COX-2 inhibitors.
TL;DR: This work led to the discovery of compounds 4a and 8a possessing higher activity than Celecoxib on cellular assay, and the regio-isomeric analogues-2-phenyl-3-sulfonyl phenyl-indoles were identified as potent and selective COX-2 inhibitors.
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Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.
TL;DR: The results showed that both M2 and M4 are potential COXs inhibitors with a moderate COX-1/COX-2 selectivity, and their anti-inflammatory activity in vivo was equal to or slightly higher than the clinical celecoxib.
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Acryloylamino-salicylanilides as EGFR PTK inhibitors
TL;DR: A series of acryloylamino-salicylanilides were synthesized as inhibitors of EGFR PTK using a strategy of pseudo six-membered ring formed through intramolecular hydrogen bonding to mimic the planar pyrimidine ring of quinazoline EGFR inhibitors.