F
Ferdinand Roelfsema
Researcher at Leiden University
Publications - 113
Citations - 4927
Ferdinand Roelfsema is an academic researcher from Leiden University. The author has contributed to research in topics: Growth hormone secretion & Acromegaly. The author has an hindex of 41, co-authored 113 publications receiving 4684 citations. Previous affiliations of Ferdinand Roelfsema include University Medical Center Utrecht & Leiden University Medical Center.
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Journal ArticleDOI
An amplitude-specific divergence in the pulsatile mode of growth hormone (GH) secretion underlies the gender difference in mean GH concentrations in men and premenopausal women.
TL;DR: Discrete peak detection by Cluster was employed as a complementary half-life-independent technique to assign variations in serum GH into pulsatile and basal fractions over 24 h, and the mechanisms underlying the increase in serumGH concentration pulse amplitude, duration, and area were investigated.
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Determinants of survival in treated acromegaly in a single center: predictive value of serial insulin-like growth factor I measurements.
Nienke R. Biermasz,Friedo W. Dekker,Alberto M. Pereira,Sjoerd W. van Thiel,Pieter J. Schutte,Hans van Dulken,Johannes A. Romijn,Ferdinand Roelfsema +7 more
TL;DR: Of the three remission criteria, IGF-I was the only one to be significantly associated with survival in this study, with a relative risk of 4.78 for an elevated as opposed to a normal IGF-i concentration, and the effects of these predictors became less significant with increasing follow-up duration.
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High prevalence of long‐term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma
Alberto M. Pereira,Eva M. Schmid,Pieter J. Schutte,J. H. C. Voormolen,Nienke R. Biermasz,Sjoerd W. van Thiel,Eleonora P M Corssmit,Jan W. A. Smit,Ferdinand Roelfsema,Johannes A. Romijn +9 more
TL;DR: The treatment of craniopharyngiomas is associated with long‐term morbidity and the use of chemotherapy is recommended to reduce the risk of recurrence.
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Disease-specific impairments in quality of life during long-term follow-up of patients with different pituitary adenomas.
Agatha A. van der Klaauw,Marleen Kars,Nienke R. Biermasz,Ferdinand Roelfsema,Olaf M. Dekkers,Eleonora P M Corssmit,Maarten O. van Aken,Bas Havekes,Alberto M. Pereira,Hanno Pijl,Johannes W. A. Smit,Johannes A. Romijn +11 more
TL;DR: Age‐ and gender‐specific standard deviations (SD) scores (Z‐scores) of QoL parameters in patients treated for pituitary adenomas are compared.
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Long-Term Follow-Up Results of Postoperative Radiotherapy in 36 Patients with Acromegaly
TL;DR: The use of radiotherapy is supported as an effective intervention in the treatment of residual clinical activity of disease after surgery for acromegaly using both the normalization of GH suppression during oral glucose loading (GTT) and IGF-I concentration as criteria for remission.