Fereshteh Jahanbani

TL;DR: New mechanistic and functional insights are revealed into regulatory region organization in the nucleus into cohesin, CTCF, and ZNF143 as key components of three-dimensional chromatin structure and how the distal chromatin state affects gene transcription.

TL;DR: This work introduces an RNA sequencing method, synthetic long-read RNA sequencing (SLR-RNA-seq), in which small pools of full-length cDNAs are amplified, fragmented and short-read-sequenced, and indicates conserved mechanisms that can produce distant but phased features on transcript and proteome isoforms.

TL;DR: It is shown that fibroblast cultures from old mice secrete inflammatory cytokines and exhibit increased variability in the efficiency of iPS cell reprogramming between mice, which may reflect distinct stochastic ageing trajectories between individuals and could help in developing personalized strategies to improve iPScell generation and wound healing in elderly individuals.

TL;DR: It is shown that patient-specific induced pluripotent stem cell-derived cardiomyocytes generated from LVNC patients carrying a mutation in the cardiac transcription factor TBX20 recapitulate a key aspect of the pathological phenotype at the single-cell level and this was associated with perturbed transforming growth factor beta (TGF-β) signalling.

TL;DR: This work presents an analysis of a human gut microbiome using TruSeq synthetic long reads combined with computational tools for metagenomic long-read assembly, variant calling and haplotyping (Nanoscope and Lens), identifying 178 bacterial species.