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Fischer Je

Researcher at Harvard University

Publications -  20
Citations -  1941

Fischer Je is an academic researcher from Harvard University. The author has contributed to research in topics: Hepatic encephalopathy & Parenteral nutrition. The author has an hindex of 9, co-authored 20 publications receiving 1917 citations.

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Journal ArticleDOI

False neurotransmitters and hepatic failure.

TL;DR: This hypothesis is consistent with many clinical and biochemical observations about hepatic failure, hepatic coma, and the "hepatorenal syndrome" and may explain the beneficial effects of L-dopa on the mental and circulatory status of patients in hepatic Failure and the satisfactory treatment of the hepatorenal Syndrome with large doses of metaraminol or other α-adrenergic amines.
Journal Article

The effect of normalization of plasma amino acids on hepatic encephalopathy in man.

TL;DR: Whereas amino acid infusion appears to be a valuable, efficacious way of providing nutrition in treating hepatic encephalopathy in patients with cirrhosis and acute deterioration and coma, other means of therapy such as plasms "laundering" appear to be necessary in Patients with fulminant hepatitis.
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Improved survival from acute renal failure after treatment with intravenous essential L-amino acids and glucose. Results of a prospective, double-blind study.

TL;DR: Analysis of indexes of renal function suggested more rapid recovery from acute renal failure in patients treated with renal-failure fluid, and survival differences were more apparent in higher-risk patients.
Journal ArticleDOI

Insulin, glucagon, aminoacid imbalance, and hepatic encephalopathy

TL;DR: Hepatic encephalopathy (H.E.) is associated with and perhaps caused by changes in plasma-aminoacid patterns--decreased branched-chain aminoacids (B.C.A.A.), and may reflect a "catabolic stimulus" reflected in hyperglucagonaemia, particularly in severe hepatic failure and H.E.
Journal Article

An improved nonsuture method for portacaval anastomosis in the rat.

TL;DR: A nonsuture technique is described for performing portacaval anastomoses in rats, which allows a single operator to perform 25 such operations per day, thus substantially increasing the availability of these animals for studies in hepatic metabolism following portacavals.