Ross J. Baldessarini

TL;DR: In the absence of adequate prospective, randomized drug-drug comparisons, the present findings provide broad, international, expert consensus-based recommendations for most clinically employed antipsychotic drugs that can support clinical practice, trial design, and interpretation of comparative antipsychotics trials.

TL;DR: Overall, less than half of patients diagnosed with schizophrenia have shown substantial clinical improvement after follow-up averaging nearly 6 years, despite considerable gains in improvement rates after mid-century, there has been a decline since the 1970s.

TL;DR: This review considers the discovery of clozapine; its chemistry, pharmacologic activities, metabolism, and pharmacokinetics; evidence of its efficacy; and its side effects and appropriate clinical use.

TL;DR: This hypothesis is consistent with many clinical and biochemical observations about hepatic failure, hepatic coma, and the "hepatorenal syndrome" and may explain the beneficial effects of L-dopa on the mental and circulatory status of patients in hepatic Failure and the satisfactory treatment of the hepatorenal Syndrome with large doses of metaraminol or other α-adrenergic amines.