F
Flora Tang
Researcher at New York University
Publications - 5
Citations - 1976
Flora Tang is an academic researcher from New York University. The author has contributed to research in topics: Receptor tyrosine kinase & Platelet-derived growth factor receptor. The author has an hindex of 5, co-authored 5 publications receiving 1891 citations.
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Journal Article
SU6668 Is a Potent Antiangiogenic and Antitumor Agent That Induces Regression of Established Tumors
A. Douglas Laird,Peter Vajkoczy,Laura K. Shawver,Andreas Thurnher,Congxin Liang,Moosa Mohammadi,Joseph Schlessinger,Axel Ullrich,Stevan R. Hubbard,Robert A. Blake,T. Annie T. Fong,Laurie M. Strawn,Li Sun,Cho Tang,Rachael E. Hawtin,Flora Tang,Narmada Shenoy,K. Peter Hirth,Gerald McMahon,Julie M. Cherrington +19 more
TL;DR: Oral or i.p. administration of SU6668 in athymic mice resulted in significant growth inhibition of a diverse panel of human tumor xenografts of glioma, melanoma, lung, colon, ovarian, and epidermoid origin, and intravital multifluorescence videomicroscopy of C6glioma xenografteds in the dorsal skinfold chamber model revealed thatSU6668 treatment suppressed tumor angiogenesis.
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Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.
TL;DR: Structural-activity analysis supports the use of subsets of 3-substituted indolin-2-ones as specific chemical leads for the development of RTK-specific drugs with broad application for the treatment of human diseases.
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Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase.
Li Sun,Chris Liang,Sheri Shirazian,Yong Zhou,Todd W. Miller,Jean Cui,Juri Y Fukuda,Ji-Yu Chu,Asaad S. Nematalla,Xueyan Wang,Hui Chen,Anand Sistla,Tony C Luu,Flora Tang,James Wei,Cho Tang +15 more
TL;DR: 5-Fluoro-2-oxo-1, 2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide (12b or SU11248) has been found to show the best overall profile in terms of potency for the VEGF-R2 and PDGF-Rbeta tyros
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Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Li Sun,Ngoc Tran,Congxin Liang,Flora Tang,Audie Rice,Randall E. Schreck,Kara Waltz,Laura K. Shawver,Gerald Mcmahon,Cho Tang +9 more
TL;DR: Three classes of 3-substituted indolin-2-ones containing propionic acid functionality attached to the pyrrole ring at the C-3 position of the core have been identified as catalytic inhibitors of the vascular endothelial growth factor, fibroblast growth factor receptor, and platelet-derived growth factor RTKs.
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Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases.
Li Sun,Ngoc Tran,Congxing Liang,Steve Hubbard,Flora Tang,Kenneth Lipson,Randall E. Schreck,Yong Zhou,Gerald McMahon,Cho Tang +9 more
TL;DR: Evidence is provided to support the potential of these new tyrosine kinase inhibitors for the treatment of angiogenesis and other growth factor-related diseases including human cancers.