F
Florence I. Roullet
Researcher at McMaster University
Publications - 11
Citations - 1444
Florence I. Roullet is an academic researcher from McMaster University. The author has contributed to research in topics: Autism & Neurodevelopmental disorder. The author has an hindex of 8, co-authored 9 publications receiving 1239 citations. Previous affiliations of Florence I. Roullet include St. Joseph's Healthcare Hamilton & National Institutes of Health.
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In utero exposure to valproic acid and autism — A current review of clinical and animal studies
TL;DR: A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.
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Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice
Mu Yang,Ozlem Bozdagi,Maria Luisa Scattoni,Maria Luisa Scattoni,Markus Wöhr,Markus Wöhr,Florence I. Roullet,Adam M. Katz,Danielle N. Abrams,David Kalikhman,Harrison Simon,Leuk Woldeyohannes,James Zhang,Mark J. Harris,Roheeni Saxena,Jill L. Silverman,Joseph D. Buxbaum,Jacqueline N. Crawley +17 more
TL;DR: The exquisite specificity of deletions in discrete domains within the Shank3 gene in determining severity of symptoms is demonstrated, and null and heterozygous mutations in the ankyrin repeat domain in Shank3 mice are reported.
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Communication Impairments in Mice Lacking Shank1: Reduced Levels of Ultrasonic Vocalizations and Scent Marking Behavior
TL;DR: Evidence for low levels of ultrasonic vocalizations and scent marks in Shank1 −/− mice as compared to wildtype Shank1 +/+ littermate controls is revealed, consistent with a phenotype relevant to social communication deficits in autism.
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Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid.
TL;DR: The results support the validity of the VPA mouse model for human autism and suggest that alterations in plasticity-related genes may contribute to the behavioral phenotype.
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Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism
TL;DR: The findings support the interpretation that BTBR incorporate communication deficits, and suggest that scent marking and ultrasonic vocalizations offer promising measures of interest in social cues that may be widely applicable to investigations of mouse models of autism.