F
Florian Wrensch
Researcher at University of Strasbourg
Publications - 22
Citations - 932
Florian Wrensch is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Viral entry & Coronavirus. The author has an hindex of 12, co-authored 22 publications receiving 707 citations. Previous affiliations of Florian Wrensch include German Primate Center & Leibniz Association.
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Journal ArticleDOI
The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies
Stefanie Gierer,Stephanie Bertram,Franziska Kaup,Florian Wrensch,Adeline Heurich,Annika Krämer-Kühl,Kathrin Welsch,Michael Winkler,Benjamin Meyer,Christian Drosten,Ulf Dittmer,Thomas von Hahn,Graham Simmons,Heike Hofmann,Stefan Pöhlmann +14 more
TL;DR: It is found that the spike protein of hCoV-EMC (EMC-S) is incorporated into lentiviral particles and mediates transduction of human cell lines derived from different organs, as well as primary human macrophages.
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IFITM Proteins Inhibit Entry Driven by the MERS-Coronavirus Spike Protein: Evidence for Cholesterol-Independent Mechanisms
TL;DR: Results show that the emerging MERS-CoV is a target of the antiviral activity of IFITM proteins and demonstrate that mechanisms other than accumulation of endosomal cholesterol can contribute to viral entry inhibition by IFITMs.
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Liver Disease and Coronavirus Disease 2019: From Pathogenesis to Clinical Care.
TL;DR: This review summarizes the current knowledge of SARS-CoV-2 virus-host interactions in the liver as well the clinical impact of liver disease in COVID-19.
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Interferon-Induced Transmembrane Protein–Mediated Inhibition of Host Cell Entry of Ebolaviruses
Florian Wrensch,Christina B. Karsten,Kerstin Gnirß,Markus Hoffmann,Kai Lu,Ayato Takada,Michael Winkler,Graham Simmons,Stefan Pöhlmann +8 more
TL;DR: Insight is provided into the role of IFITM proteins in infection by ebolaviruses and a mechanism by which antibodies, though poorly neutralizing in vitro, might contribute to viral control in vivo is suggested.
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Analysis of Ebola Virus Entry Into Macrophages
Franziska Dahlmann,Nadine Biedenkopf,Anne Babler,Willi Jahnen-Dechent,Christina B. Karsten,Kerstin Gnirß,Heike Schneider,Florian Wrensch,Christopher A. O’Callaghan,Stephanie Bertram,Georg Herrler,Stephan Becker,Stefan Pöhlmann,Heike Hofmann-Winkler +13 more
TL;DR: It is shown that mannose-specific lectins, TIM-1 and Axl augment entry into certain cell lines but do not contribute to Ebola virus (EBOV)-glycoprotein (GP)–driven transduction of macrophages, and the concept that EBOV relies on apoptotic mimicry to invade target cells is supported.