H
Heike Hofmann
Researcher at University of Erlangen-Nuremberg
Publications - 24
Citations - 3412
Heike Hofmann is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Coronavirus & Receptor. The author has an hindex of 19, co-authored 24 publications receiving 2996 citations. Previous affiliations of Heike Hofmann include University of Pennsylvania & German Primate Center.
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Journal ArticleDOI
Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry
TL;DR: It is shown that SARS-CoV shares its receptor ACE2 with HCoV-NL63, which suggests that highly pathogenic variants have ample opportunity to evolve, underlining the need for vaccines against HCoVs.
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Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63
Ilona Glowacka,Stephanie Bertram,Petra Herzog,Susanne Pfefferle,Imke Steffen,Imke Steffen,Imke Steffen,Marcus O. Muench,Graham Simmons,Heike Hofmann,Thomas Kuri,Friedemann Weber,Friedemann Weber,Friedemann Weber,Jutta Eichler,Christian Drosten,Stefan Pöhlmann +16 more
TL;DR: It was found that recombinant SARS-S bound to ACE2 and induced ACE2 shedding with higher efficiency than NL63-S and replicated efficiently in ACE2-positive Vero cells and reduced ACE2 expression, indicating robust receptor interference in the context of SARS but not NL63 infection.
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The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies
Stefanie Gierer,Stephanie Bertram,Franziska Kaup,Florian Wrensch,Adeline Heurich,Annika Krämer-Kühl,Kathrin Welsch,Michael Winkler,Benjamin Meyer,Christian Drosten,Ulf Dittmer,Thomas von Hahn,Graham Simmons,Heike Hofmann,Stefan Pöhlmann +14 more
TL;DR: It is found that the spike protein of hCoV-EMC (EMC-S) is incorporated into lentiviral particles and mediates transduction of human cell lines derived from different organs, as well as primary human macrophages.
Journal ArticleDOI
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.
Heike Hofmann,Martina Geier,Andrea Marzi,Mandy Krumbiegel,Matthias Peipp,Georg H. Fey,Thomas Gramberg,Stefan Pöhlmann +7 more
TL;DR: The results point to a central role of ACE2 in SARS-CoV infection and suggest a minor contribution of the cytoplasmic domain to receptor function, which is not important for receptor function.
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DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets
Chawaree Chaipan,Elizabeth J. Soilleux,Peter Simpson,Heike Hofmann,Heike Hofmann,Thomas Gramberg,Andrea Marzi,Martina Geier,Elizabeth A. Stewart,Jutta Eisemann,Alexander Steinkasserer,Katsue Suzuki-Inoue,Gemma L.J. Fuller,Andrew C. Pearce,Steve P. Watson,James A. Hoxie,Frédéric Baribaud,Stefan Pöhlmann +17 more
TL;DR: It is shown that platelets express both the C-type lectin-like receptor 2 (CLEC-2) and low levels of DC-SIGN, indicating that these lectins are required for efficient HIV-1 binding to platelets and providing evidence that platelet-associated virus remains infectious and can escape degradation by platelets.