F
Francesco Marchesi
Researcher at University of Glasgow
Publications - 82
Citations - 3425
Francesco Marchesi is an academic researcher from University of Glasgow. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 18, co-authored 36 publications receiving 2902 citations. Previous affiliations of Francesco Marchesi include University of Milan & Mario Negri Institute for Pharmacological Research.
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Journal ArticleDOI
Interleukin-1β Immunoreactivity and Microglia Are Enhanced in the Rat Hippocampus by Focal Kainate Application: Functional Evidence for Enhancement of Electrographic Seizures
Annamaria Vezzani,Mirko Conti,Ada De Luigi,Teresa Ravizza,D. Moneta,Francesco Marchesi,Maria Grazia De Simoni +6 more
TL;DR: Exogenous application of IL-1β prolongs kainate-induced hippocampal EEG seizures by enhancing glutamatergic neurotransmission and thus, convulsant and/or excitotoxic stimuli increase the production of interleukin (IL)-1β in microglia-like cells in the hippocampus.
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Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway.
Alessandra Insinga,Silvia Monestiroli,Simona Ronzoni,Vania Gelmetti,Francesco Marchesi,Andrea Viale,Lucia Altucci,Clara Nervi,Saverio Minucci,Pier Giuseppe Pelicci +9 more
TL;DR: Results show that sensitivity to HDACIs in leukemias is a property of the fully transformed phenotype and depends on activation of a specific death pathway.
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Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus
Maria Grazia De Simoni,Carlo Perego,Teresa Ravizza,D. Moneta,Mirko Conti,Francesco Marchesi,Ada De Luigi,Silvio Garattini,Annamaria Vezzani +8 more
TL;DR: The induction of spontaneously recurring seizures in rats involves the activation of inflammatory cytokines and related pro‐ and anti‐inflammatory genes in the hippocampus and these changes may play an active role in hyperexcitability of the epileptic tissue.
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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
Chiara Gorrini,Massimo Squatrito,Massimo Squatrito,Chiara Luise,Nelofer Syed,Daniele Perna,Landon Wark,Francesca Martinato,Domenico Sardella,Alessandro Verrecchia,Samantha Bennett,Stefano Confalonieri,Matteo Cesaroni,Francesco Marchesi,Milena Gasco,Eugenio Scanziani,Maria Capra,Sabine Mai,Paolo Nuciforo,Tim Crook,John Lough,Bruno Amati +21 more
TL;DR: In both mouse and human, Tip60 has a haplo-insufficient tumour suppressor activity that is independent from—but not contradictory with—its role within the ARF–p53 pathway.
Journal ArticleDOI
UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome
Roland Hjerpe,John S. Bett,John S. Bett,Matthew J. Keuss,Alexandra S. Solovyova,Thomas G. McWilliams,Clare Johnson,Indrajit Sahu,Joby Varghese,Nicola T. Wood,Melanie Wightman,Georgina F. Osborne,Gillian P. Bates,Michael H. Glickman,Matthias Trost,Axel Knebel,Francesco Marchesi,Thimo Kurz,Thimo Kurz +18 more
TL;DR: A new pathway for maintaining protein homeostasis mediated by the proteasome shuttle factor UBQLN2 is described, which is active in the cell nucleus, where another system for aggregate clearance, autophagy, does not act.