Francesco Zorzato

TL;DR: Haplotyping suggests that the mutation in all five breeds of lean, heavily muscled swine has a common origin, and the development of a noninvasive diagnostic test will provide the basis for elimination of the MH gene or its controlled inclusion in swine breeding programs.

TL;DR: Analysis of the cDNAs encoding the rabbit and human forms of the Ca2+ release channel of sarcoplasmic reticulum indicates that 10 potential transmembrane sequences in the COOH-terminal fifth of the molecule and two additional, potential trans membrane sequences nearer to the center of the molecules could contribute to the formation of theCa2+ conducting pore.

TL;DR: It is demonstrated that muscle mTORC1 has an unexpected role in the regulation of the metabolic properties and that its function is essential for life.

TL;DR: Analysis of predicted secondary structures and hydropathy plots suggests that the two isoforms exhibit the same topology in both transmembrane and cytoplasmic domains, and suggests that a modulator binding domain in the protein lies between residues 2619 and 3016.

TL;DR: Co-segregation of MH with RYRmarkers, resulting in a lod score of 4.20 at a linkage distance of zero centimorgans, indicates that MH is likely to be caused by mutations in the RYR gene.