R
Robert G. Korneluk
Researcher at University of Ottawa
Publications - 172
Citations - 19764
Robert G. Korneluk is an academic researcher from University of Ottawa. The author has contributed to research in topics: Inhibitor of apoptosis & XIAP. The author has an hindex of 59, co-authored 171 publications receiving 19153 citations. Previous affiliations of Robert G. Korneluk include Children's Hospital of Eastern Ontario & Boston Children's Hospital.
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Journal ArticleDOI
NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation
TL;DR: Tumor necrosis factor alpha binding to the TNF receptor (TNFR) potentially initiates apoptosis and activates the transcription factor nuclear factor kappa B (NF-kappaB), which suppresses apoptosis by an unknown mechanism.
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Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
Peter Liston,Natalie Roy,Katsuyuki Tamai,Charles Lefebvre,Charles Lefebvre,Stephen Baird,Cherton-Horvat G,Cherton-Horvat G,Ramin Mostofi Zadeh Farahani,Ramin Mostofi Zadeh Farahani,M. McLean,Joh-E Ikeda,Alex MacKenzie,Alex MacKenzie,Robert G. Korneluk,Robert G. Korneluk +15 more
TL;DR: A NAIP-mediated inhibition of apoptosis induced by a variety of signals is demonstrated, and three additional human complementary DNAs and a Drosophila melanogaster sequence that are also homologous to the baculovirus lAPs are identified.
Journal ArticleDOI
The inhibitors of apoptosis (IAPs) and their emerging role in cancer.
Eric C. LaCasse,Stephen Baird,Stephen Baird,Robert G. Korneluk,Robert G. Korneluk,Alex MacKenzie,Alex MacKenzie +6 more
TL;DR: A picture consistent with an IAP role in tumour progression rather than tumour initiation is emerging making the IAPs an attractive therapeutic target.
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The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy
Natalie Roy,Natalie Roy,Mani S. Mahadevan,Michael Mclean,Michael Mclean,Gary Shutter,Zahra Yaraghi,Zahra Yaraghi,Reza Farahani,Reza Farahani,Stephen Baird,Anne Besner-Johnston,Charles Lefebvre,Charles Lefebvre,Xiaolin Kang,Xiaolin Kang,Maysoon Salih,Huguette L. Aubry,Katsuyuki Tamai,Xiaoping Guan,Panayiotis A. Ioannou,Thomas O. Crawford,Pieter J. de Jong,Linda C. Surh,Joh-E Ikeda,Joh-E Ikeda,Robert G. Korneluk,Robert G. Korneluk,Alex MacKenzie,Alex MacKenzie +29 more
TL;DR: It is suggested that mutations in the NAIP locus may lead to a failure of a normally occurring inhibition of motor neuron apoptosis resulting in or contributing to the SMA phenotype.
Journal ArticleDOI
Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK
Brian Zarnegar,Yaya Wang,Douglas J. Mahoney,Paul W. Dempsey,Herman H. Cheung,Jeannie He,Travis L. Shiba,Xiaolu Yang,Wen-chen Yeh,Tak W. Mak,Robert G. Korneluk,Genhong Cheng +11 more
TL;DR: The lethality of TRAF3 deficiency in mice could be rescued by a single NIK gene, highlighting the importance of tightly regulated NIK.