Francine Gossé

TL;DR: Resveratrol caused a significant decrease of ornithine decarboxylase (ODC) activity, a key enzyme of polyamine biosynthesis, which is enhanced in cancer growth, and resulted in the reduction of the intracellular putrescine content, indicating that polyamines might represent one of several targets involved in the anti-proliferative effects of resver atrol.

TL;DR: This study suggests that S.bovis acts as a promoter of early preneoplastic lesions in the colon of rats and the fact that bacterial wall proteins are more potent inducers of neoplastic transformation than the intact bacteria may have important implications in colon cancer prevention.

TL;DR: The results show that apple procyanidins alter intracellular signaling pathways, polyamine biosynthesis and trigger apoptosis in tumor cells and antagonize cancer promotion in vivo.

TL;DR: The results show a relationship between the pro-inflammatory potential of S.bovis proteins and their pro-carcinogenic properties, confirming the linkage between inflammation and colon carcinogenesis and support the hypothesis that colonic bacteria can contribute to cancer development particularly in chronic infection/inflammation diseases.

TL;DR: The high potency and efficacy of resveratrol support its use as a chemopreventive agent in the management of intestinal carcinogenesis and highlight the complexity of the events associated with intestinal tumorigenesis and the multiplicity of the molecular targets of res veratrol.