Françoise Finiels

TL;DR: It is shown that FALSG93A mice suffer from motoneurone dysfunction similar to that observed in ALS patients and fulfill Lambert's criteria for ALS, and a massive loss of functional motor units starting at 47 days of age.

TL;DR: Although adenoviruses are highly attractive for neuronal gene transfer, they can trigger a strong inflammatory reaction leading in particular to the destruction of infected cells, so the use of these new vectors, combined with that of neurospecific and regulatable promoters, should improveAdenovirus gene transfer into the central nervous system.

TL;DR: The results suggest that NT-3 delivery by adenovirus-based gene therapy is a promising strategy for the prevention of both early diabetic neuropathy and axonal neuropathies, especially late axonal diabetes neuropathy.

TL;DR: It is shown that specific and high yield gene transfer into motor neurones can be obtained by peripheral intramuscular injections of recombinant adenoviruses, and Gene transfer can be specifically targeted to particular regions of the spinal cord by appropriate choice of the injected muscle.

TL;DR: NRSEs restricted expression of the luciferase gene to neuronal cells in vivo when adenoviruses were injected both intramuscularly into mice and intracerebrally into rats, which may allow the direct transfection of motor neurons without promoting transgene expression within inoculated muscles or the secretion of transGene products into the bloodstream.