F
Frank G. Favaloro
Researcher at Dartmouth College
Publications - 17
Citations - 1016
Frank G. Favaloro is an academic researcher from Dartmouth College. The author has contributed to research in topics: Oleanane & Nitric oxide. The author has an hindex of 9, co-authored 15 publications receiving 964 citations.
Papers
More filters
Journal ArticleDOI
Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages.
Tadashi Honda,BarbieAnn V. Rounds,Lothar Bore,Heather Finlay,Frank G. Favaloro,Nanjoo Suh,Yongping Wang,Michael B. Sporn,Gordon W. Gribble +8 more
TL;DR: The selected oleanane triterpenoid, CDDO, was found to be a potent, multifunctional agent in various in vitro assays and to show antiinflammatory activity against thioglycollate-interferon-gamma-induced mouse peritonitis.
Journal ArticleDOI
A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production.
Tadashi Honda,Yukiko Honda,Frank G. Favaloro,Gordon W. Gribble,Nanjoo Suh,Andrew E. Place,Mara H. Rendi,Michael B. Sporn +7 more
TL;DR: 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile shows extremely high inhibitory activity (IC(50)=1 pM level) against production of nitric oxide induced by interferon-gamma in mouse macrophages.
Journal ArticleDOI
Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages.
Tadashi Honda,Gordon W. Gribble,Nanjoo Suh,Heather Finlay,Barbie Ann V. Rounds,Lothar Bore,Frank G. Favaloro,Yongping Wang,Michael B. Sporn +8 more
TL;DR: Preliminary screening of these derivatives for inhibition of production of nitric oxide induced by interferon-gamma in mouse macrophages revealed that 3-oxooleana-1, 12-dien-28-oic acid (B-15) showed significant activity, although 3 does not act through the glucocorticoid receptor.
Journal ArticleDOI
Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages
Tadashi Honda,BarbieAnn V. Rounds,Lothar Bore,Frank G. Favaloro,Gordon W. Gribble,Nanjoo Suh,Yongping Wang,Michael B. Sporn +7 more
TL;DR: Novel oleanane triterpenoids with modified rings A and C showed similar high inhibitory activity to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), which has been synthesized previously, against production of nitric oxide induced by interferon-gamma in mouse macrophages.
Journal ArticleDOI
Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents.
Tadashi Honda,Hidenori Yoshizawa,Chitra Sundararajan,Emilie David,Marc J. Lajoie,Frank G. Favaloro,Tomasz Janosik,Xiaobo Su,Yukiko Honda,Bill D. Roebuck,Gordon W. Gribble +10 more
TL;DR: TCE 31 is the most potent in these bioassays in the authors' pool of drug candidates including semisynthetic triterpenoids and synthetic tricycles, suggesting that an essential factor for potency is not a triter penoid skeleton but the cyano enone functionality.