F
Frank J. Godinho
Researcher at Howard Hughes Medical Institute
Publications - 7
Citations - 955
Frank J. Godinho is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: GATA1 & Acute megakaryoblastic leukemia. The author has an hindex of 6, co-authored 7 publications receiving 878 citations. Previous affiliations of Frank J. Godinho include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
Developmental stage–selective effect of somatically mutated leukemogenic transcription factor GATA1
Zhe Li,Frank J. Godinho,Frank J. Godinho,Jan-Henning Klusmann,Mireia Garriga-Canut,Channing Yu,Channing Yu,Stuart H. Orkin +7 more
TL;DR: It is shown that the dominant action of GATA1s leads to hyperproliferation of a unique, previously unrecognized yolk sac and fetal liver progenitor, which is proposed accounts for the transient nature of TMD and the restriction of DS-AMKL to infants.
Journal ArticleDOI
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia
Jan-Henning Klusmann,Zhe Li,Katarina Böhmer,Aliaksandra Maroz,Mia Lee Koch,Stephan Emmrich,Frank J. Godinho,Stuart H. Orkin,Dirk Reinhardt +8 more
TL;DR: The role of Hsa21-encoded miR-125b-2, a microRNA overexpressed in DS-AMKL/TL, in hematopoiesis and leukemogenesis is investigated and proposed as a positive regulator of megakaryopoiedis and an oncomiR involved in the pathogenesis of trisomy 21-associatedmegakaryoblastic leukemia.
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ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients
Esther Baena,Zhen Shao,Zhen Shao,Douglas E. Linn,Kimberly Glass,Melanie J. Hamblen,Melanie J. Hamblen,Melanie J. Hamblen,Yuko Fujiwara,Yuko Fujiwara,Yuko Fujiwara,Jonghwan Kim,Jonghwan Kim,Minh Nguyen,Minh Nguyen,Xin Zhang,Frank J. Godinho,Frank J. Godinho,Frank J. Godinho,Roderick T. Bronson,Lorelei A. Mucci,Massimo Loda,Guo-Cheng Yuan,Stuart H. Orkin,Stuart H. Orkin,Stuart H. Orkin,Zhe Li,Zhe Li,Zhe Li +28 more
TL;DR: The distinct biology of ETV1-associated prostate cancer suggests that this disease class may require new therapies directed to underlying programs controlled by ETV2, and the association of an ETV 1 expression signature with aggressive disease and poorer outcome in patient data is confirmed.
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ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.
Zhe Li,Cristina E. Tognon,Frank J. Godinho,Frank J. Godinho,Laura Yasaitis,Hanno Hock,Hanno Hock,Jason I. Herschkowitz,Chris L. Lannon,Eun Ah Cho,Seong-Jin Kim,Roderick T. Bronson,Charles M. Perou,Poul H. Sorensen,Stuart H. Orkin +14 more
TL;DR: A mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma, provides genetic evidence that, in nulliparous Wap-Cre;EN females, committed alveolar bipotent or CD61(+) luminal progenitors are targets of tumorigenesis.
Journal ArticleDOI
Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis
Jan-Henning Klusmann,Frank J. Godinho,Kirsten Heitmann,Aliaksandra Maroz,Mia Lee Koch,Dirk Reinhardt,Stuart H. Orkin,Zhe Li +7 more
TL;DR: This study addresses the vexing issue of how developmental restriction is achieved in Down syndrome acute megakaryoblastic leukemia (DS-AMKL), and explains resistance to transformation of ostensibly similar adult progenitors.