F
Frank McCormick
Researcher at University of California, San Francisco
Publications - 406
Citations - 70141
Frank McCormick is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: MAPK/ERK pathway & Signal transduction. The author has an hindex of 117, co-authored 381 publications receiving 64610 citations. Previous affiliations of Frank McCormick include University of California, Berkeley & University of California.
Papers
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Journal ArticleDOI
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.
Osamu Tetsu,Frank McCormick +1 more
TL;DR: It is shown that β-catenin activates transcription from the cyclin D1 promoter, and that sequences within the promoter that are related to consensus TCF/LEF-binding sites are necessary for activation.
Journal ArticleDOI
The GTPase superfamily: conserved structure and molecular mechanism
TL;DR: GTPases are conserved molecular switches, built according to a common structural design, and rapidly accruing knowledge of individual GTPases—crystal structures, biochemical properties, or results of molecular genetic experiments—support and generate hypotheses relating structure to function in other members of the diverse family of GTPase.
Journal ArticleDOI
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
Richard M. Neve,Richard M. Neve,Koei Chin,Jane Fridlyand,Jennifer Yeh,Frederick L. Baehner,Tea Fevr,Laura Clark,Nora Bayani,Jean-Philippe Coppe,Frances Tong,Terence P. Speed,Paul T. Spellman,Sandy DeVries,Anna Lapuk,Nicholas J. Wang,Wen-Lin Kuo,Jackie L. Stilwell,Daniel Pinkel,Donna G. Albertson,F. M. Waldman,Frank McCormick,Robert B. Dickson,Michael D. Johnson,Marc E. Lippman,Stephen P. Ethier,Adi F. Gazdar,Joe W. Gray,Joe W. Gray +28 more
TL;DR: It is shown, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations.
Journal ArticleDOI
The GTPase superfamily: a conserved switch for diverse cell functions
TL;DR: A molecular switch is a molecular switch whose "on" and "off" states are triggered by binding and hydrolysis of GTP as discussed by the authors. But the mechanism in myriad versions of the switch can be traced back to a single primordial protein.
Journal ArticleDOI
Proteins regulating Ras and its relatives.
Mark S. Boguski,Frank McCormick +1 more
TL;DR: Many of these proteins are much larger and more complex than their targets, containing multiple domains capable of interacting with an intricate network of cellular enzymes and structures.