F
Frank Schweizer
Researcher at University of Manitoba
Publications - 160
Citations - 6490
Frank Schweizer is an academic researcher from University of Manitoba. The author has contributed to research in topics: Efflux & Pseudomonas aeruginosa. The author has an hindex of 37, co-authored 151 publications receiving 5323 citations. Previous affiliations of Frank Schweizer include University of Lethbridge & University of Alberta.
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Synthesis of fluorescently labelled and internally quenched UDP-Gal probes.
TL;DR: The results demonstrate that galactose-modified, sugar-nucleotide-modified and double modified UDP-Gal analogues are recognized as weak substrates by blood group B alpha-(1-->3) galactosyltransferase, alpha-( 1-->3).
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Structure activity relationships of N-linked and diglycosylated glucosamine-based antitumor glycerolipids.
TL;DR: Three N-linked (glycosylamide) analogs 2–4, one triazole-linked analog 5 of 1 as well as two diglycosylated analogs 6 and 7 with different stereochemistry at the C2-position of the glycerol moiety were synthesized and their antitumor activity against breast, pancreas and prostrate cancer cell lines was determined.
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Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria
George G. Zhanel,Marianna Pozdirca,Alyssa R Golden,Courtney K. Lawrence,Sheryl A. Zelenitsky,Liam Berry,Frank Schweizer,Denice C. Bay,Heather J. Adam,Michael A. Zhanel,Philippe Lagacé-Wiens,Andrew Walkty,Neal Irfan,Kurt G. Naber,Joseph P. Lynch,James A. Karlowsky +15 more
TL;DR: Sulopenem is an intravenous and oral penem that possesses in vitro activity against fluoroquinolone-resistant, extended spectrum β-lactamases (ESBL)-producing, multidrug-resistant (MDR) Enterobacterales and is being developed to treat patients with uncomplicated and complicated urinary tract infections (UTIs) as well as intra-abdominal infections.
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Synthesis, Inhibitory Effects on Nitric Oxide and Structure-Activity Relationships of a Glycosphingolipid from the Marine Sponge Aplysinella rhax and Its Analogues
Yuzo Fujita,Naohiro Ohshima,Ai Hasegawa,Frank Schweizer,Tadahiro Takeda,Fumiyuki Kiuchi,Noriyasu Hada +6 more
TL;DR: The results indicate that both the presence of a D-Fucα1-3GlcNAc-linkage and the ceramide aglycon portion are crucial for optimal NO inhibition.
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Glycosamino Acids: Building Blocks for Combinatorial Synthesis — Implications for Drug Discovery.
TL;DR: Glycosamino acids are hybrid structures of carbohydrates and amino acids which can be utilized to generate potential glycomimetics and peptidomimetics as discussed by the authors, which can also influence the pharmacokinetic and dynamic properties of the peptides.