Franklin Vargas

TL;DR: In this paper, the synthesis and characterization of metal imidazole complexes showing activity against Trypanosoma cruzi, the causative agent of Chagas disease, are presented.

TL;DR: Furosemide photosensitized the peroxidation of linoleic acid, as monitored by the UV-detection of dienic hydroperoxides and it also photosenitized the oxidation of histidine.

TL;DR: While parent compounds showed very little or no phototoxicity, the most toxic photoproducts were systematically the benzylic alcohols, which showed lytic activity to erythrocytes and cytotoxicity to cultured fibroblasts, which partly explain the in vivo photot toxicity of this family of drugs.

TL;DR: In this article, the ability of emodin, aloe-emodin and rhein to inhibit free-radical or reactive oxygen species (OH, 1O2, H2O2) generated in cell-free systems using isoluminol and luminol-enhanced chemiluminescence and electronic absorption spectra was investigated.

TL;DR: Fenofibrate was phototoxic in vitro when examined by the photohemolysis test, both under oxygen and argon atmosphere, although the photoemolysis rate was markedly lower under anaerobic conditions, which can be explained through the involvement of free radicals, singlet oxygen and stable photoproducts.