Fred C. Davis

TL;DR: CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity.

TL;DR: The pacemaker role of the suprachiasmatic nucleus in a mammalian circadian system was tested by neural transplantation by using a mutant strain of hamster that shows a short circadian period to restore circadian rhythms to arrhythmic animals whose own nucleus had been ablated.

TL;DR: A comparative analysis of circadian gene expression in vivo in mouse liver and heart using oligonucleotide arrays representing 12,488 genes finds that peripheral circadian gene regulation is extensive, that the distributions of circadian phases in the two tissues are markedly different, and that very few genes show circadian regulation in both tissues.

TL;DR: The results implicate EGF receptor signaling in the daily control of locomotor activity, and identify a neural circuit in the hypothalamus that likely mediates the regulation of behavior both by the SCN and the retina.

TL;DR: In this article, a targeted disruption of the Otx-like homeobox gene Crx has been proposed to have a role in the regulation of photoreceptor-specific genes in the eye and of pineal-specific gene in the pineal gland.