F
Frederick Meins
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 89
Citations - 9094
Frederick Meins is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Nicotiana tabacum & Gene. The author has an hindex of 59, co-authored 89 publications receiving 8786 citations. Previous affiliations of Frederick Meins include Syngenta & Novartis.
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Journal ArticleDOI
Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing
Todd Blevins,Rajendran Rajeswaran,Padubidri V. Shivaprasad,Daria Beknazariants,Azeddine Si-Ammour,Hyun Sook Park,Franck Vazquez,Dominique Robertson,Frederick Meins,Thomas Hohn,Thomas Hohn,Mikhail M. Pooggin +11 more
TL;DR: This work highlights the complexity of virus interaction with host silencing pathways and suggests that DCL multiplicity helps mediate plant responses to diverse viral infections.
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Regulation of a plant pathogenesis-related enzyme: Inhibition of chitinase and chitinase mRNA accumulation in cultured tobacco tissues by auxin and cytokinin
TL;DR: Two endochitinases (EC 3.2.1.14) of M(r) values of approximately 34,000 and approximately 32,000 have been purified from cultured tissues of Nicotiana tabacum cv, indicating that chitinase accumulation is controlled, at least in part, at the mRNA level.
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A short C-terminal sequence is necessary and sufficient for the targeting of chitinases to the plant vacuole
TL;DR: Results demonstrate that the C-terminal extension of tobacco chitinase A is necessary and sufficient for the vacuolar localization of chit inases and, therefore, that it comprises a targeting signal for plant vacuoles.
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Structure of a tobacco endochitinase gene: evidence that different chitinase genes can arise by transposition of sequences encoding a cysteine-rich domain.
TL;DR: The sequences encoding the cysteine-rich domain in class I chitinases are flanked by 9–10 bp imperfect direct repeats suggesting that these domains arose from a common ancestral gene and were introduced into genes for class I enzymes by transposition events.
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High molecular weight RNAs and small interfering RNAs induce systemic posttranscriptional gene silencing in plants
Ulrich Gerhard Klahre,Patrice Crete,Sabrina A. Leuenberger,Victor Alejandro Iglesias,Frederick Meins +4 more
TL;DR: This work uses a positive marker system and real-time monitoring of green fluorescent protein expression to show that large sense, antisense, and double-stranded RNAs as well as double- Stranded siRNAs delivered biolistically into plant cells trigger silencing capable of spreading locally and systemically.