F
Fredi Rojo
Researcher at Autonomous University of Barcelona
Publications - 1
Citations - 2423
Fredi Rojo is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: mTORC2 & Insulin receptor. The author has an hindex of 1, co-authored 1 publications receiving 2323 citations.
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mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
Kathryn E. O'Reilly,Fredi Rojo,Qing-Bai She,David B. Solit,Gordon B. Mills,Debra G. Smith,Heidi Lane,Francesco Hofmann,Daniel J. Hicklin,Dale L. Ludwig,José Baselga,Neal Rosen +11 more
TL;DR: The data suggest that feedback down-regulation of receptor tyrosine kinase signaling is a frequent event in tumor cells with constitutive mTOR activation, and reversal of this feedback loop by rapamycin may attenuate its therapeutic effects, whereas combination therapy that ablates mTOR function and prevents Akt activation may have improved antitumor activity.