F
Friedhelm Bladt
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 8
Citations - 3708
Friedhelm Bladt is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Hepatocyte growth factor & Receptor tyrosine kinase. The author has an hindex of 8, co-authored 8 publications receiving 3622 citations. Previous affiliations of Friedhelm Bladt include University of Cambridge.
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Journal ArticleDOI
Scatter factor/hepatocyte growth factor is essential for liver development
C Schmidt,Friedhelm Bladt,S Goedecke,Volker Brinkmann,W Zschiesche,M Sharpe,Ermanno Gherardi,Carmen Birchmeier +7 more
TL;DR: It is reported that mice lacking SF/HGF fail to complete development and die in utero, and the mutation affects the embryonic liver, which is reduced in size and shows extensive loss of parenchymal cells.
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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud.
TL;DR: It is reported that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and for migration into diaphragm and tip of tongue.
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Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons
Allen Ebens,Katja Brose,E.David Leonardo,M.Gartz Hanson,Friedhelm Bladt,Carmen Birchmeier,Ben A. Barres,Marc Tessier-Lavigne +7 more
TL;DR: Results indicate that, in addition to functioning as a mitogen, a motogen, and a morphogen in nonneural systems, HGF/SF can function as a guidance and survival factor in the developing nervous system.
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The role of SF/HGF and c-Met in the development of skeletal muscle.
Susanne Dietrich,Faikah Abou-Rebyeh,Henning Brohmann,Friedhelm Bladt,Eva Sonnenberg-Riethmacher,Tomoichiro Yamaai,Andrew Lumsden,Beate Brand-Saberi,Carmen Birchmeier +8 more
TL;DR: It is shown that parallel but independent cues converge on the migratory hypaxial precursors in the dermomyotomal lip after they are laid down: a signal given by SF/HGF that controls the emigration of the precursor, and an as yet unidentified signal that controls Lbx1.
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The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons
Adele Caton,Adam Hacker,Arifa Naeem,Jean Livet,Flavio Maina,Friedhelm Bladt,Rüdiger Klein,Carmen Birchmeier,Sarah Guthrie +8 more
TL;DR: Branchial arch tissue may act as a target-derived factor that guides motor axons during development and is likely to be mediated partly by Hepatocyte Growth Factor, although a component of branchial arch-mediated growth promotion and chemoattraction was not blocked by anti-HGF antibodies.