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Volker Brinkmann
Researcher at Max Planck Society
Publications - 176
Citations - 36708
Volker Brinkmann is an academic researcher from Max Planck Society. The author has contributed to research in topics: Neutrophil extracellular traps & Antigen. The author has an hindex of 68, co-authored 172 publications receiving 32085 citations. Previous affiliations of Volker Brinkmann include Novartis & Max Delbrück Center for Molecular Medicine.
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Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
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Novel cell death program leads to neutrophil extracellular traps
Tobias A. Fuchs,Ulrike Abu Abed,Christian Goosmann,Robert Hurwitz,Ilka Schulze,Volker Wahn,Yvette Weinrauch,Volker Brinkmann,Arturo Zychlinsky +8 more
TL;DR: This novel ROS-dependent death allows neutrophils to fulfill their antimicrobial function, even beyond their lifespan.
Journal ArticleDOI
Scatter factor/hepatocyte growth factor is essential for liver development
C Schmidt,Friedhelm Bladt,S Goedecke,Volker Brinkmann,W Zschiesche,M Sharpe,Ermanno Gherardi,Carmen Birchmeier +7 more
TL;DR: It is reported that mice lacking SF/HGF fail to complete development and die in utero, and the mutation affects the embryonic liver, which is reduced in size and shows extensive loss of parenchymal cells.
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Netting neutrophils in autoimmune small-vessel vasculitis.
Kai Kessenbrock,Markus Krumbholz,Ulf Schönermarck,Walter Back,Wolfgang Gross,Zena Werb,Hermann-Josef Gröne,Volker Brinkmann,Dieter E. Jenne +8 more
TL;DR: It is shown that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 and myeloperoxidase (MPO).
Journal ArticleDOI
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
Marie-Luise von Brühl,Konstantin Stark,Alexander Steinhart,Sue Chandraratne,Ildiko Konrad,Michael Lorenz,Alexander G. Khandoga,Anca Tirniceriu,Raffaele Coletti,Maria Köllnberger,Robert A. Byrne,Iina Laitinen,Axel Walch,Alexander Brill,Susanne Pfeiler,Davit Manukyan,Siegmund Braun,Philipp S. Lange,Julia Riegger,Jerry Ware,Annekathrin Eckart,Selgai Haidari,Martina Rudelius,Christian Schulz,Katrin Echtler,Volker Brinkmann,Markus Schwaiger,Klaus T. Preissner,Denisa D. Wagner,Nigel Mackman,Bernd Engelmann,Steffen Massberg +31 more
TL;DR: Deep vein thrombosis initiation is mediated by cross talk between monocytes, neutrophils, and platelets.