G
G. Cristina Brailoiu
Researcher at Thomas Jefferson University
Publications - 68
Citations - 3985
G. Cristina Brailoiu is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Receptor & Ryanodine receptor. The author has an hindex of 28, co-authored 67 publications receiving 3551 citations. Previous affiliations of G. Cristina Brailoiu include Jefferson College & East Tennessee State University James H. Quillen College of Medicine.
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Journal ArticleDOI
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system
Eugen Brailoiu,Siok L. Dun,G. Cristina Brailoiu,Keisuke Mizuo,Larry A. Sklar,Tudor I. Oprea,Eric R. Prossnitz,Nae J. Dun +7 more
TL;DR: A high expression of irGPR30 is shown in the hypothalamic-pituitary axis, hippocampal formation, and brainstem autonomic nuclei; and the activation of GPR30 by G-1 is associated with a mobilization of calcium in dissociated and cultured rat hypothalamic neurons.
Journal ArticleDOI
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
Eugen Brailoiu,Dev Churamani,Xinjiang Cai,Michael G. Schrlau,G. Cristina Brailoiu,Xin Gao,Robert Hooper,Michael J. Boulware,Nae J. Dun,Jonathan S. Marchant,Sandip Patel +10 more
TL;DR: It is shown that the previously uncharacterized human two-pore channels (TPC1 and TPC2) are endolysosomal proteins, that NAADP-mediated calcium signals are enhanced by overexpression of T PC1 and attenuated after knockdown of TPC1, and that mutation of a single highly conserved residue within a putative pore region abrogated calcium release byNAADP.
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Regulatory Role of G Protein–Coupled Estrogen Receptor for Vascular Function and Obesity
Elvira Haas,Indranil Bhattacharya,Eugen Brailoiu,Marlen Damjanović,G. Cristina Brailoiu,Xin Gao,Laurence Mueller-Guerre,Nicole A. Marjon,Andre Gut,Roberta Minotti,Matthias R. Meyer,Kerstin Amann,Emerita Ammann,Ana Perez-Dominguez,Michele Genoni,Deborah J. Clegg,Nae J. Dun,Thomas C. Resta,Eric R. Prossnitz,Matthias Barton +19 more
TL;DR: It is found that the selective stimulation of the intracellular, transmembrane G protein-coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial blood vessels.
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Nesfatin-1: Distribution and Interaction with a G Protein-Coupled Receptor in the Rat Brain
G. Cristina Brailoiu,Siok L. Dun,Eugen Brailoiu,Saadet Inan,Jun Yang,Jaw Kang Chang,Nae J. Dun +6 more
TL;DR: The result shows that irNEF is distributed to several discrete nuclei in the brainstem, in addition to the hypothalamus and NTS reported earlier, and that the peptide interacts with a G protein-coupled receptor, leading to an increase of [Ca(2+)](i), which is linked to protein kinase A activation in cultured rat hypothalamic neurons.
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Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro.
TL;DR: Results from the in vivo and in vitro studies together with the previous observation of the presence of orexin A-immunoreactive fibers in the IML suggest that orexins, when released within the IML, augment sympathetic outflow by acting directly on SPNs.