G
G. K. Whitfield
Researcher at University of Arizona
Publications - 21
Citations - 3399
G. K. Whitfield is an academic researcher from University of Arizona. The author has contributed to research in topics: Calcitriol receptor & Retinoid X receptor. The author has an hindex of 16, co-authored 21 publications receiving 3287 citations.
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Journal ArticleDOI
The nuclear vitamin D receptor: biological and molecular regulatory properties revealed.
Mark R. Haussler,G. K. Whitfield,Carol A. Haussler,J. C. Hsieh,Paul Thompson,S. H. Selznick,Carlos Encinas Dominguez,Peter W. Jurutka +7 more
TL;DR: The scope of this review will be limited to highlighting the actions of 1,25(OH)2D3 mediated by nuclear VDR and discussing new developments in the structure/function analysis of the receptor, including the phenotype of VDR knockout mice and the biochemical classification of patients with point mutations in the receptor.
Journal ArticleDOI
The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB
Peter W. Jurutka,L. S. Remus,G. K. Whitfield,Paul Thompson,Jui Cheng Hsieh,H. Zitzer,P. Tavakkoli,Michael A. Galligan,Htl Dang,Carol A. Haussler,Mark R. Haussler +10 more
TL;DR: It is concluded that the functioning of positively charged Arg-18/Arg-22 as part of an hVDR docking site for TFIIB is influenced by the composition of the adjacent polymorphic N terminus, and increased transactivation by the F/M4 neomorphic HVDR is hypothesized to result from its demonstrated enhanced association withTFIIB.
Journal ArticleDOI
The vitamin D hormone and its nuclear receptor: molecular actions and disease states
Mark R. Haussler,Carol A. Haussler,Peter W. Jurutka,Paul Thompson,J. C. Hsieh,L. S. Remus,S. H. Selznick,G. K. Whitfield +7 more
TL;DR: Vitamin D responsive elements (VDREs) consisting of direct hexanucleotide repeats with a spacer of three nucleotides have been identified in the promoter regions of positively controlled genes expressed in bone, such as osteocalcin, osteopontin, beta 3-integrin and vitamin D 24-OHase.
Journal ArticleDOI
Molecular Nature of the Vitamin D Receptor and its Role in Regulation of Gene Expression
Peter W. Jurutka,G. K. Whitfield,Jui Cheng Hsieh,Paul Thompson,Carol A. Haussler,Mark R. Haussler +5 more
TL;DR: The fact that the phenotype of HVDRR patients, excluding alopecia, mimics classic nutritional as well as renal rickets, indicates that 1,25(OH)2D3-liganded VDR not only executes the bone mineral homeostatic actions of vitamin D, but suggests that VDR also participates in the normal hair growth cycle in skin.
Journal ArticleDOI
Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner.
G. K. Whitfield,S. H. Selznick,Carol A. Haussler,J. C. Hsieh,Michael A. Galligan,Peter W. Jurutka,Paul Thompson,S M Lee,J E Zerwekh,Mark R. Haussler +9 more
TL;DR: The unique properties of these genetically altered receptors establish a new subclass of natural human VDR mutants that illustrate, in vivo, the importance of both 1,25-(OH)2D3 binding and heterodimerization with RXR in VDR action.